{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:44:32Z","timestamp":1759963472989},"reference-count":14,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T00:00:00Z","timestamp":1288310400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,3]]},"abstract":"Abstract<\/jats:title>Objective:<\/jats:title>This study aimed to demonstrate the histological and immunohistological features of skin biopsy specimens from patients complaining of isolated itching of the external auditory canal.<\/jats:p><\/jats:sec>Materials and methods:<\/jats:title>A prospective, case\u2013control study was performed of 24 patients undergoing evaluation for contact dermatitis of the external auditory canal, and 24 controls. Skin biopsies were examined histologically by a single, blinded dermatopathologist, using light microscopy, to determine histopathological characteristics. The immunohistological presence of the antimicrobial peptides human \u03b2-defensin-3 and LL-37 cathelicidin was also assessed. Findings for patients and controls were compared.<\/jats:p><\/jats:sec>Results:<\/jats:title>There was a statistically significant difference in the degree of inflammation, comparing patients and controls (p<\/jats:italic>\u00a0<\u00a00.05). There was no significant difference in the presence of spongiotic changes, comparing patients and controls (p<\/jats:italic>\u00a0>\u00a00.05). Furthermore, the patients' skin biopsies did not show pronounced expression of human \u03b2-defensin-3 or LL-37 cathelicidin.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Histological and immunohistological examination of skin biopsies from cases of isolated itching of the external auditory canal did not support a diagnosis of dermatitis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110002161","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T09:48:14Z","timestamp":1288345694000},"page":"227-230","source":"Crossref","is-referenced-by-count":7,"title":["Isolated itching of external auditory canal: clinicopathological study with immunohistochemical determination of antimicrobial peptides"],"prefix":"10.1017","volume":"125","author":[{"given":"B","family":"Acar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G G\u00fcler","family":"Simsek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Oguztuzun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Zaim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R Murat","family":"Karasen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2010,10,29]]},"reference":[{"key":"S0022215110002161_ref3","first-page":"221","volume-title":"Textbook of Contact Dermatitis","author":"Goh","year":"1995"},{"key":"S0022215110002161_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000231562.83733.53"},{"key":"S0022215110002161_ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.24.15258"},{"key":"S0022215110002161_ref14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05014.x"},{"key":"S0022215110002161_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90154-Q"},{"key":"S0022215110002161_ref12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008557200"},{"key":"S0022215110002161_ref4","doi-asserted-by":"publisher","DOI":"10.1094\/MPMI-8-0006"},{"key":"S0022215110002161_ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.19507.x"},{"key":"S0022215110002161_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0325z.x"},{"key":"S0022215110002161_ref9","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0030-6665(20)31815-6","article-title":"Allergic disorders in the otolaryngologic practice","volume":"18","author":"King","year":"1985","journal-title":"Otolaryngol Clin North Am"},{"key":"S0022215110002161_ref10","first-page":"333","article-title":"Treatment of itching ears with fluocinolone acetonide","volume":"53","author":"Mabry","year":"1974","journal-title":"Eye Ear Nose Throat Mon"},{"key":"S0022215110002161_ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.018003177.x"},{"key":"S0022215110002161_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109991459"},{"key":"S0022215110002161_ref11","volume-title":"Pathology of the Skin","author":"Farmer","year":"2000"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110002161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T21:13:15Z","timestamp":1636751595000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110002161\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10,29]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0022215110002161"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110002161","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10,29]]}}}