{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T12:46:15Z","timestamp":1793277975055,"version":"4.5.0"},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T00:00:00Z","timestamp":1290643200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110002446_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>We studied the incidence and bacterial epidemiology of acute epiglottitis presenting in the first 16 years following the introduction of general childhood vaccination against <jats:italic>Haemophilus influenzae<\/jats:italic> type b. Our main objectives were to analyse (1) the incidence of <jats:italic>Streptococcus pneumoniae<\/jats:italic> epiglottitis in adults and (2) the distribution of pneumococcal serotypes involved.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002446_sec2\"><jats:title>Materials and methods:<\/jats:title><jats:p>The medical records of patients with acute epiglottitis (International Classification of Disease code J05.1) were investigated. <jats:italic>Streptococcus pneumoniae<\/jats:italic> serotyping was performed using gel precipitation.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002446_sec3\"><jats:title>Results:<\/jats:title><jats:p>The overall incidence of acute epiglottitis was 0.98 cases\/100 000\/year, compared with 4.5 cases\/100 000\/year before the vaccination programme. The incidence was reduced both in children and adults, compared with pre-vaccination values. However, the incidence of <jats:italic>Streptococcus pneumoniae<\/jats:italic> epiglottitis in adults increased from 0.1 to 0.28 cases\/100 000\/year over the same time period. The causative agent was <jats:italic>Streptococcus pneumoniae<\/jats:italic> in 10 adults. Nine of 10 pneumococcal strains could be serotyped. All but one serotype is represented in the 23-valent pneumococcal polysaccharide vaccine (PPV23) used in adults.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002446_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>In acute epiglottitis, now a disease of adults, the most important bacterial aetiology is <jats:italic>Streptococcus pneumoniae<\/jats:italic>. The serotype distribution found in this study indicates that the infection is preventable by PPV-23 vaccination with the 23-valent polysaccharide vaccine.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110002446","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T07:05:16Z","timestamp":1290668716000},"page":"390-393","source":"Crossref","is-referenced-by-count":36,"title":["Acute epiglottitis: epidemiology and <i>Streptococcus pneumoniae<\/i> serotype distribution in adults"],"prefix":"10.1017","volume":"125","author":[{"given":"M","family":"Isakson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Hugosson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,11,25]]},"reference":[{"key":"S0022215110002446_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1994.tb01265.x"},{"key":"S0022215110002446_ref5","first-page":"3531","article-title":"Acute epiglottitis now affecting adults is mainly caused by pneumococci. Important to observe the incidence when considering future vaccination strategy [in Swedish]","volume":"104","author":"Isakson","year":"2007","journal-title":"Akut epiglottit: nu vuxensjukdom fr\u00e4mst orsakad av pneumokocker"},{"key":"S0022215110002446_ref13","doi-asserted-by":"publisher","DOI":"10.3109\/00365549609027169"},{"key":"S0022215110002446_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00393-2"},{"key":"S0022215110002446_ref11","doi-asserted-by":"publisher","DOI":"10.1080\/080352500750028212"},{"key":"S0022215110002446_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198605013141801"},{"key":"S0022215110002446_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.038"},{"key":"S0022215110002446_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2005.00909.x"},{"key":"S0022215110002446_ref4","doi-asserted-by":"publisher","DOI":"10.1136\/adc.65.5.491"},{"key":"S0022215110002446_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107000473"},{"key":"S0022215110002446_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000422.pub2"},{"key":"S0022215110002446_ref6","unstructured":"6 Statistics, Sweden [in Swedish]. In: http:\/\/www.scb.se [18 February 2010]"},{"key":"S0022215110002446_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/003655498750002303"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110002446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T15:09:08Z","timestamp":1556377748000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110002446\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,25]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0022215110002446"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110002446","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,25]]}}}