{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T21:09:44Z","timestamp":1783199384684,"version":"3.54.6"},"reference-count":7,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T00:00:00Z","timestamp":1290643200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110002483_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Cerebrospinal fluid leakage is the most common complication of endoscopic trans-sphenoidal pituitary surgery. However, there is no uniformly accepted way of managing this complication when it occurs intra-operatively. This paper describes a quick, simple technique, involving layered fibrin glue and gelatin sponge, which does not compromise post-operative patient follow up.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002483_sec2\"><jats:title>Method:<\/jats:title><jats:p>Retrospective review of all endoscopic pituitary surgery cases conducted at a single institution since the introduction of this technique in 2002.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002483_sec3\"><jats:title>Results:<\/jats:title><jats:p>A total of 120 endoscopic pituitary operations were performed (96 primary procedures and 24 revisions). All intra-operative cerebrospinal fluid leaks were managed using the described method, with a failure rate of 3.6 per cent. The overall post-operative leakage rate was 1.7 per cent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002483_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This simple, conservative technique avoids the need for further dissection and the use of non-absorbable foreign material, and has a low incidence of post-operative cerebrospinal fluid leakage.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110002483","type":"journal-article","created":{"date-parts":[[2010,11,25]],"date-time":"2010-11-25T07:10:25Z","timestamp":1290669025000},"page":"311-313","source":"Crossref","is-referenced-by-count":25,"title":["Management of intra-operative cerebrospinal fluid leak following endoscopic trans-sphenoidal pituitary surgery"],"prefix":"10.1017","volume":"125","author":[{"given":"C G L","family":"Hobbs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Darr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W V","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2010,11,25]]},"reference":[{"key":"S0022215110002483_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2006.06.043"},{"key":"S0022215110002483_ref6","first-page":"885","article-title":"Collagen sponge repair of small cerebrospinal fluid leaks obviates tissue grafts and cerebrospinal fluid diversion after pituitary surgery","volume":"49","author":"Kelly","year":"2001","journal-title":"Neurosurgery"},{"key":"S0022215110002483_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.surneu.2004.01.016"},{"key":"S0022215110002483_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.5.576"},{"key":"S0022215110002483_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2008.02.017"},{"key":"S0022215110002483_ref2","doi-asserted-by":"publisher","DOI":"10.1086\/515533"},{"key":"S0022215110002483_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100119486"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110002483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T15:31:45Z","timestamp":1556379105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110002483\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,25]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0022215110002483"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110002483","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,25]]}}}