{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:42:58Z","timestamp":1761237778163},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T00:00:00Z","timestamp":1296086400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215110002872_sec1\"><jats:title>Background:<\/jats:title><jats:p>We present a rare case of primary mucosal melanoma of the middle ear imaged with 18F-fluoro-2-deoxy-<jats:sc>d<\/jats:sc>-glucose positron emission tomography\/computed tomography (FDG-PET\/CT).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002872_sec2\"><jats:title>Method:<\/jats:title><jats:p>Clinical, radiological, intra-operative and histological findings are discussed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002872_sec3\"><jats:title>Results:<\/jats:title><jats:p>An 88-year-old woman presented with intermittent otorrhoea of the left ear for several months. Otoscopy revealed a livid protrusion of the tympanic membrane. Melanoma was not suspected initially, but was established on transmembranous biopsy. Pre-operative 18F-fluoro-2-deoxy-<jats:sc>d<\/jats:sc>-glucose positron emission tomography\/computed tomography revealed a mass lesion in the left tympanic cavity with high fluoro-deoxyglucose uptake, as well as an ipsilateral intraparotid lymph node metastasis. The patient underwent surgical treatment. The diagnosis of melanoma was confirmed histologically.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215110002872_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>In this rare case, clinical, radiological and surgical findings led to the diagnosis of a primary mucosal melanoma of the middle ear.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215110002872","type":"journal-article","created":{"date-parts":[[2011,1,27]],"date-time":"2011-01-27T08:11:40Z","timestamp":1296115900000},"page":"536-539","source":"Crossref","is-referenced-by-count":6,"title":["Melanoma of the middle ear: initial presentation, Fluoro-2-deoxy-<scp>d<\/scp>-glucose positron emission tomography\/computed tomography imaging and follow up"],"prefix":"10.1017","volume":"125","author":[{"given":"M W","family":"Huellner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Cousin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Linder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Soyka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Bussmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Eberle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Strobel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,1,27]]},"reference":[{"key":"S0022215110002872_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200202000-00032"},{"key":"S0022215110002872_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.04.001"},{"key":"S0022215110002872_ref13","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1998.88.1.0011"},{"key":"S0022215110002872_ref11","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.54.3.131"},{"key":"S0022215110002872_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(78)90201-3"},{"key":"S0022215110002872_ref15","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3635"},{"key":"S0022215110002872_ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198411000-00012"},{"key":"S0022215110002872_ref18","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2493080240"},{"key":"S0022215110002872_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(11)61033-1"},{"key":"S0022215110002872_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.10.010"},{"key":"S0022215110002872_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.9.1126"},{"key":"S0022215110002872_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10019"},{"key":"S0022215110002872_ref8","first-page":"100","article-title":"Primary malignant mucosal melanoma of the head and neck","volume":"14","author":"Bradley","year":"2006","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"S0022215110002872_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)70937-5"},{"key":"S0022215110002872_ref4","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100118195"},{"key":"S0022215110002872_ref12","first-page":"687","article-title":"Clinical presentation, natural history and prognostic factors in advanced malignant melanoma","volume":"149","author":"Amer","year":"1979","journal-title":"Surg Gynecol Obstet"},{"key":"S0022215110002872_ref16","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2004.06.001"},{"key":"S0022215110002872_ref17","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.03.5634"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215110002872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T04:51:13Z","timestamp":1556340673000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215110002872\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,27]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0022215110002872"],"URL":"https:\/\/doi.org\/10.1017\/s0022215110002872","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,27]]}}}