{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T06:26:43Z","timestamp":1712816803457},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T00:00:00Z","timestamp":1297728000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111000053_sec1\"><jats:title>Aims:<\/jats:title><jats:p>To analyse intratympanic gentamicin injection as a treatment option in patients with monolateral M\u00e9ni\u00e8re's disease resistant to medical treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111000053_sec2\"><jats:title>Material and methods:<\/jats:title><jats:p>Longitudinal, prospective, descriptive study of response to gentamicin treatment in 71 patients diagnosed with M\u00e9ni\u00e8re's disease and treated medically for more than a year, unsuccessfully. American Academy of Otolaryngology-Head and Neck Surgery criteria were used for diagnosis and follow up.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111000053_sec3\"><jats:title>Results:<\/jats:title><jats:p>Complete vertigo control was obtained in 65.6 per cent of patients, and complete or substantial control in 84.37 per cent. Thirteen patients (18.3 per cent) suffered significant hearing loss.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111000053_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This intratympanic gentamicin injection protocol enabled effective vertigo control in most patients, and represents a good alternative to more aggressive techniques for the treatment of M\u00e9ni\u00e8re's disease which does not respond to medical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111000053","type":"journal-article","created":{"date-parts":[[2011,2,15]],"date-time":"2011-02-15T17:16:47Z","timestamp":1297790207000},"page":"363-369","source":"Crossref","is-referenced-by-count":9,"title":["Intratympanic gentamicin in M\u00e9ni\u00e8re's disease: our experience"],"prefix":"10.1017","volume":"125","author":[{"given":"L P\u00e9rez","family":"Delgado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J Fraile","family":"Rodrigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P Astier","family":"Pe\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,2,15]]},"reference":[{"key":"S0022215111000053_ref27","doi-asserted-by":"publisher","DOI":"10.1258\/002221503321046586"},{"key":"S0022215111000053_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200002010-00009"},{"key":"S0022215111000053_ref24","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/mao.0b013e3180577963","article-title":"Current management of M\u00e9ni\u00e8re's disease in an only hearing ear","volume":"28","author":"Peterson","year":"2007","journal-title":"Otol Neurotol"},{"key":"S0022215111000053_ref23","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00009"},{"key":"S0022215111000053_ref22","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510500188X"},{"key":"S0022215111000053_ref21","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200103000-00016"},{"key":"S0022215111000053_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200401000-00018"},{"key":"S0022215111000053_ref16","doi-asserted-by":"publisher","DOI":"10.3109\/00016488109133278"},{"key":"S0022215111000053_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200008000-00014"},{"key":"S0022215111000053_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0988-0"},{"key":"S0022215111000053_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/BF00455886"},{"key":"S0022215111000053_ref6","first-page":"209","article-title":"Intratympanic gentamicin for control of vertigo in Meniere's disease: vestibular signs that specify completion of therapy","volume":"20","author":"Minor","year":"1999","journal-title":"Am J Otol"},{"key":"S0022215111000053_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"},{"key":"S0022215111000053_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200207000-00018"},{"key":"S0022215111000053_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318065aa27"},{"key":"S0022215111000053_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00013"},{"key":"S0022215111000053_ref2","first-page":"1","article-title":"Ablation therapy in the management of Meni\u00e8re's disease","volume":"132","author":"Schuknecht","year":"1957","journal-title":"Acta Otolaryngol Suppl"},{"key":"S0022215111000053_ref7","first-page":"44","article-title":"Intratympanic gentamicin therapy for M\u00e9ni\u00e8re's disease","volume":"18","author":"Hirsch","year":"1997","journal-title":"Am J Otol"},{"key":"S0022215111000053_ref15","doi-asserted-by":"publisher","DOI":"10.3109\/00016488209128885"},{"key":"S0022215111000053_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.06.002"},{"key":"S0022215111000053_ref14","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196709000-00003"},{"key":"S0022215111000053_ref1","first-page":"293","article-title":"Toxicity of streptomycin for the auditory and vestibular mechanisms","volume":"52","author":"Fowler","year":"1948","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"S0022215111000053_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70103-6"},{"key":"S0022215111000053_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00023"},{"key":"S0022215111000053_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31802c300c"},{"key":"S0022215111000053_ref11","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/00016489850183359","article-title":"Intratympanic gentamicin in M\u00e9ni\u00e8re's disease","volume":"118","author":"Kaasinen","year":"1998","journal-title":"Acta Otolaryngol"},{"key":"S0022215111000053_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199701000-00012"}],"container-title":["The Journal of Laryngology &amp; 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