{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:00:46Z","timestamp":1787061646126,"version":"build-2736575974"},"reference-count":25,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T00:00:00Z","timestamp":1297382400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215111000065_sec1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess the effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray, used in conjunction with antibiotic treatment, on the intensity of clinical signs and quality of life of patients with group A streptococcal tonsillopharyngitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215111000065_sec2\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0147) with streptococcal tonsillopharyngitis were recruited and randomly allocated to either the treatment group (penicillin plus chlorhexidine and benzydamine;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a072) or control group (penicillin plus placebo;\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a075). Blinded assessments were conducted before and after 10 days' treatment, using an intensity rating scale for clinical sign severity, a visual analogue scale for subjective health state, the Short Form 36 Health Questionnaire for quality of life, and a customised questionnaire for side effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215111000065_sec3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The treatment group showed a statistically significant reduction in the intensity of clinical signs, compared with the control group. On treatment day 7, there was no significant difference in quality of life between the treatment and control groups. The treatment drugs were well tolerated, and no serious adverse events were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215111000065_sec4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Chlorhexidine gluconate and benzydamine hydrochloride mouth spray, added to standard antibiotic treatment, significantly alleviate the intensity of clinical signs in patients with streptococcal pharyngitis. Further research is needed using larger sample sizes or alternative control groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215111000065","type":"journal-article","created":{"date-parts":[[2011,2,11]],"date-time":"2011-02-11T04:59:44Z","timestamp":1297400384000},"page":"620-625","source":"Crossref","is-referenced-by-count":21,"title":["Effect of chlorhexidine gluconate and benzydamine hydrochloride mouth spray on clinical signs and quality of life of patients with streptococcal tonsillopharyngitis: multicentre, prospective, randomised, double-blinded, placebo-controlled study"],"prefix":"10.1017","volume":"125","author":[{"given":"C","family":"Cingi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Songu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Ural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Erdogmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Cakli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,2,11]]},"reference":[{"key":"S0022215111000065_ref19","first-page":"255","article-title":"Susceptibility of various microorganisms to chlorhexidine","volume":"85","author":"Emilson","year":"1977","journal-title":"Scand J Dent Res"},{"key":"S0022215111000065_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02397.x"},{"key":"S0022215111000065_ref16","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290101.x"},{"key":"S0022215111000065_ref4","article-title":"Antibiotics for sore throat","volume":"4","author":"Del Mar","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"S0022215111000065_ref22","first-page":"801","article-title":"In vitro experiments with chlorhexidine on pure bacterial and fungal cultures from the mouth","volume":"64","author":"Hesselgren","year":"1971","journal-title":"Swed Dent J"},{"key":"S0022215111000065_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1977.tb00050.x"},{"key":"S0022215111000065_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(00)70339-8"},{"key":"S0022215111000065_ref18","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199039010-00005"},{"key":"S0022215111000065_ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01782.x"},{"key":"S0022215111000065_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/nur.4770130405"},{"key":"S0022215111000065_ref10","doi-asserted-by":"publisher","DOI":"10.1086\/340949"},{"key":"S0022215111000065_ref14","first-page":"212","article-title":"Rational use of antibiotics in pediatrics: impact of a rapid test for detection of beta-haemolytic group A streptococci in acute pharyngotonsillitis [in Spanish]","volume":"52","author":"Spadetto","year":"2000","journal-title":"An Esp Pediatr"},{"key":"S0022215111000065_ref21","doi-asserted-by":"publisher","DOI":"10.1177\/00220345790580071401"},{"key":"S0022215111000065_ref1","first-page":"1529","volume-title":"Emergency Medicine: Concepts and Clinical Practice","author":"Melio","year":"1998"},{"key":"S0022215111000065_ref12","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1542\/peds.96.4.758","article-title":"Committee on Rheumatic Fever, Endocarditis, and Kawasaki Disease of the American Heart Association. Treatment of acute streptococcal pharyngitis and prevention of rheumatic fever: a statement for health professionals","volume":"96","author":"Dajani","year":"1995","journal-title":"Pediatrics"},{"key":"S0022215111000065_ref2","first-page":"1494","volume-title":"Emergency Medicine: a Comprehensive Study Guide","author":"Shores","year":"2004"},{"key":"S0022215111000065_ref3","unstructured":"3 Scottish Intercollegiate Guidelines Network. Management of Sore Throat and Indications for Tonsillectomy. Guideline No: 117 April 2010 (http:\/\/www.sign.ac.uk\/guidelines\/fulltext\/117\/index.html)"},{"key":"S0022215111000065_ref5","unstructured":"5 National Institute for Health and Clinical Excellence. NICE Guideline. Respiratory tract \u0131nfections \u2013 antibiotic prescribing. Prescribing of antibiotics for self-limiting respiratory tract \u0131nfections \u0131n adults and children in primary care. In: http:\/\/www.nice.org.uk\/nicemedia\/pdf\/CG69FullGuideline.pdf [16.01.2001]"},{"key":"S0022215111000065_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-199303000-00006"},{"key":"S0022215111000065_ref11","first-page":"68","article-title":"Making decisions at the point of care: sore throat","volume":"10","author":"Ebell","year":"2003","journal-title":"Fam Pract Manag"},{"key":"S0022215111000065_ref13","doi-asserted-by":"publisher","DOI":"10.1542\/peds.101.1.136"},{"key":"S0022215111000065_ref15","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/45.suppl_1.3"},{"key":"S0022215111000065_ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01514.x"},{"key":"S0022215111000065_ref24","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.1987.0112"},{"key":"S0022215111000065_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200201000-00016"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215111000065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T02:00:08Z","timestamp":1685930408000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215111000065\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2,11]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0022215111000065"],"URL":"https:\/\/doi.org\/10.1017\/s0022215111000065","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2,11]]}}}