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Otol."],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111000491_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the clinical course and pathological characteristics of basaloid head and neck squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111000491_sec2\"><jats:title>Method:<\/jats:title><jats:p>Retrospective study of 18 cases of basaloid head and neck squamous cell carcinoma. Epidemiological, clinical and histological data were analysed and the Kaplan\u2013Meier test used to estimate survival rates.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111000491_sec3\"><jats:title>Results:<\/jats:title><jats:p>The majority of lesions were at an advanced stage. These lesions were primarily localised in the larynx, hypopharynx and oropharynx. Routine pre-therapeutic assessment of squamous cell carcinoma was performed. Pathological diagnosis was difficult, although immunostaining was extremely useful. Positive staining for KL1, MNF 116 and 34\u03b2E12 and negative immunostaining for chromogranin and synaptophysin were also important factors in obtaining a definitive diagnosis. In the majority of cases, treatment involved surgery and radiotherapy. The five-year survival rate was 5 per cent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111000491_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Basaloid squamous cell carcinoma is an uncommon head and neck lesion, with a challenging histological diagnosis. These lesions must be carefully monitored due to their aggressive course, and require multimodality treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111000491","type":"journal-article","created":{"date-parts":[[2011,3,30]],"date-time":"2011-03-30T15:42:45Z","timestamp":1301499765000},"page":"608-613","source":"Crossref","is-referenced-by-count":11,"title":["Basaloid squamous cell carcinoma of the head and neck: report of 18 cases"],"prefix":"10.1017","volume":"125","author":[{"given":"O","family":"Choussy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Fran\u00e7ois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Blot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Hamidou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Dehesdin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,3,30]]},"reference":[{"key":"S0022215111000491_ref54","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200406000-00020"},{"key":"S0022215111000491_ref53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02345.x"},{"key":"S0022215111000491_ref52","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31816380ec"},{"key":"S0022215111000491_ref44","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/83.2.159"},{"key":"S0022215111000491_ref43","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910215)67:4<1025::AID-CNCR2820670427>3.0.CO;2-F"},{"key":"S0022215111000491_ref45","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990215)85:4<841::AID-CNCR11>3.0.CO;2-6"},{"key":"S0022215111000491_ref38","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2000.00851.x"},{"key":"S0022215111000491_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80462-0"},{"key":"S0022215111000491_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.04.014"},{"key":"S0022215111000491_ref32","first-page":"450","article-title":"Basaloid squamous cell carcinoma of the larynx: report of two cases","volume":"39","author":"Kruslin","year":"1998","journal-title":"Croat Med J"},{"key":"S0022215111000491_ref31","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1177\/014556130208100413","article-title":"Basaloid squamous cell carcinoma of the larynx: report of a case","volume":"81","author":"Prasad","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"S0022215111000491_ref29","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.1.83"},{"key":"S0022215111000491_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.09.011"},{"key":"S0022215111000491_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(02)00010-6"},{"key":"S0022215111000491_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(01)00032-X"},{"key":"S0022215111000491_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/104.5.594"},{"key":"S0022215111000491_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1994.tb01576.x"},{"key":"S0022215111000491_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880140509"},{"key":"S0022215111000491_ref16","doi-asserted-by":"publisher","DOI":"10.1177\/019459989210600206"},{"key":"S0022215111000491_ref14","first-page":"181","article-title":"Basaloid squamous cell carcinoma of the head and neck with a spindle cell component. 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