{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:58:18Z","timestamp":1792587498754,"version":"4.5.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T00:00:00Z","timestamp":1307664000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111001289_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Mucormycosis is an aggressive fungal infection which may still cause fatal complications. However, the rarity of this disease has made optimal treatment a controversial issue. This study aimed to evaluate the use of topical amphotericin B in endoscopic management of rhinocerebral mucormycosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111001289_sec2\"><jats:title>Subjects and methods:<\/jats:title><jats:p>Thirty patients with infection limited to the nose and sinuses were selected. Patients underwent endoscopic debridement of all necrotic tissue; cottonoid pledgets soaked in amphotericin B solution were then placed in the nasal cavity. Subsequently, long-term antifungal therapy was administered.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111001289_sec3\"><jats:title>Results:<\/jats:title><jats:p>The overall survival rate was 60 per cent (18 cases); survival rates in the diabetic and malignancy groups were 70.58 and 40 per cent, respectively. Apart from predisposing factors, orbital and maxillary sinus involvement also had a significant correlation with patient outcome.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111001289_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Topical use of amphotericin B combined with endoscopic surgical debridement, followed by intravenous amphotericin B treatment, may constitute acceptable management for selected patients, with less morbidity than conventional treatments.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111001289","type":"journal-article","created":{"date-parts":[[2011,6,10]],"date-time":"2011-06-10T12:51:26Z","timestamp":1307710286000},"page":"807-810","source":"Crossref","is-referenced-by-count":68,"title":["Endoscopic management of rhinocerebral mucormycosis with topical and intravenous amphotericin B"],"prefix":"10.1017","volume":"125","author":[{"given":"B","family":"Saedi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Seilani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,6,10]]},"reference":[{"key":"S0022215111001289_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-198311000-00004"},{"key":"S0022215111001289_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2006.02.053"},{"key":"S0022215111001289_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-005-0919-0"},{"key":"S0022215111001289_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00041327-199903000-00020"},{"key":"S0022215111001289_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/14.Supplement_1.S126"},{"key":"S0022215111001289_ref7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF02907665","article-title":"Rhinocerebral mucormycosis: an analysis of probable mode of spread and its implication in an early diagnosis and treatment","volume":"57","author":"Kulkarni","year":"2005","journal-title":"Indian J Otolaryngol"},{"key":"S0022215111001289_ref6","first-page":"322","article-title":"Emerging therapeutic options in fulminant invasive rhinocerebral mucormycosis","volume":"32","author":"Scheckenbach","year":"2009","journal-title":"Auris Nasus Larynx"},{"key":"S0022215111001289_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(94)95896-3"},{"key":"S0022215111001289_ref4","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.18.3.556-569.2005"},{"key":"S0022215111001289_ref9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1439-0507.2007.01364.x","article-title":"Rhinocerebral mucormycosis: the disease spectrum in 27 patients","volume":"50","author":"Gupta","year":"2007","journal-title":"Mycoses"},{"key":"S0022215111001289_ref14","doi-asserted-by":"crossref","first-page":"706","DOI":"10.3928\/1542-8877-19960801-10","article-title":"Intraconal amphotericin B for the treatment of rhinoorbital mucormycosis","volume":"27","author":"Luna","year":"1996","journal-title":"Ophthalmic Surg Lasers"},{"key":"S0022215111001289_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(00)80010-9"},{"key":"S0022215111001289_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2001.00656.x"},{"key":"S0022215111001289_ref15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00405-008-0692-y","article-title":"Rhino-orbital-cerebral mucormycosis and aspergillosis: differential diagnosis and treatment","volume":"266","author":"Aschendorff","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"S0022215111001289_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2006.01604.x"},{"key":"S0022215111001289_ref11","doi-asserted-by":"publisher","DOI":"10.2500\/105065899782106751"},{"key":"S0022215111001289_ref2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/194589240101500508","article-title":"Treatment of rhinocerebral mucormycosis by combination of endoscopic sinus debridement and amphotericin B","volume":"15","author":"Alobid","year":"2001","journal-title":"Am J Rhinol"},{"key":"S0022215111001289_ref13","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2008.22.3121"},{"key":"S0022215111001289_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(00)80010-9"}],"container-title":["The Journal of Laryngology &amp; 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