{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:46:56Z","timestamp":1778669216436,"version":"3.51.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T00:00:00Z","timestamp":1313452800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111001538_sec1\"><jats:title>Background:<\/jats:title><jats:p>Infantile haemangiomas enter a rapid proliferative phase within months of birth, before slowly involuting. Those with the potential for disfigurement or morbidity require intervention. Propranolol has emerged as an effective new treatment modality, with the potential to become the first-line treatment of choice.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111001538_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Four children with haemangiomas of the head and neck were treated with propranolol at a tertiary referral centre. The size of the haemangioma and the symptoms resulting from airway compromise were monitored.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111001538_sec3\"><jats:title>Results:<\/jats:title><jats:p>Three of the four children showed a dramatic response to treatment with propranolol. However, one child responded initially but was readmitted with stridor secondary to new haemangioma proliferation.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111001538_sec4\"><jats:title>Conclusions:<\/jats:title><jats:p>We report a cautionary case in which a subglottic haemangioma developed contemporaneously with propranolol treatment, requiring surgical intervention. This finding highlights the need for regular follow up of treatment response, and the need for monitoring for treatment side effects.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111001538","type":"journal-article","created":{"date-parts":[[2011,8,16]],"date-time":"2011-08-16T12:33:45Z","timestamp":1313498025000},"page":"1164-1172","source":"Crossref","is-referenced-by-count":18,"title":["Failure of propranolol in the treatment of childhood haemangiomas of the head and neck"],"prefix":"10.1017","volume":"125","author":[{"given":"J","family":"Goswamy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M P","family":"Rothera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I A","family":"Bruce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,8,16]]},"reference":[{"key":"S0022215111001538_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(00)80192-6"},{"key":"S0022215111001538_ref18","doi-asserted-by":"publisher","DOI":"10.1290\/1071-2690(2002)038<0298:BBIAIC>2.0.CO;2"},{"key":"S0022215111001538_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.08.020"},{"key":"S0022215111001538_ref8","first-page":"3130","article-title":"Treatment of infantile hemangiomas with low-dose propranolol: evaluation of short-term efficacy and safety [in Spanish]","volume":"89","author":"Qin","year":"2009","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"S0022215111001538_ref4","first-page":"152","article-title":"Treatment of infantile haemangiomas with propranolol [in Spanish]","volume":"68","author":"Sanchez Perez","year":"2008","journal-title":"An Pediatr (Barc)"},{"key":"S0022215111001538_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.10.010"},{"key":"S0022215111001538_ref1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1542\/peds.70.1.48","article-title":"Mast cell hemangiomas and vascular malformations","volume":"70","author":"Mulliken","year":"1982","journal-title":"Pediatrics"},{"key":"S0022215111001538_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2004.05.029"},{"key":"S0022215111001538_ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2822"},{"key":"S0022215111001538_ref20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1417"},{"key":"S0022215111001538_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03261.x"},{"key":"S0022215111001538_ref2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007-2767"},{"key":"S0022215111001538_ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"S0022215111001538_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4644(19971201)67:3<353::AID-JCB7>3.0.CO;2-V"},{"key":"S0022215111001538_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20633"},{"key":"S0022215111001538_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2009.00975.x"},{"key":"S0022215111001538_ref11","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-3458"},{"key":"S0022215111001538_ref19","first-page":"147","volume-title":"Basic and Clinical Pharmacology","author":"Hoffmann","year":"2007"},{"key":"S0022215111001538_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2010.01.001"},{"key":"S0022215111001538_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.09.136"},{"key":"S0022215111001538_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.04.025"},{"key":"S0022215111001538_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2009.12.008"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215111001538","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T20:38:55Z","timestamp":1686256735000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215111001538\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,16]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2011,11]]}},"alternative-id":["S0022215111001538"],"URL":"https:\/\/doi.org\/10.1017\/s0022215111001538","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,16]]}}}