{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,7]],"date-time":"2026-06-07T23:34:22Z","timestamp":1780875262698,"version":"3.54.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T00:00:00Z","timestamp":1315180800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111002301_sec1\"><jats:title>Aim:<\/jats:title><jats:p>The aetiology of tympanosclerosis is not yet clear. This prospective, controlled, clinical study investigated the relationship between<jats:italic>Helicobacter pylori<\/jats:italic>and tympanosclerosis aetiology.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002301_sec2\"><jats:title>Materials and methods:<\/jats:title><jats:p>The study included 14 patients with tympanosclerosis and 26 with other forms of chronic otitis media. All patients underwent surgery for chronic otitis media. Mucosal biopsies were taken, and examined for<jats:italic>H pylori<\/jats:italic>using the Campylobacter-Like Organism (CLO) test.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002301_sec3\"><jats:title>Results:<\/jats:title><jats:p>Tympanoplasty was performed in 29 patients (72.5 per cent), radical mastoidectomy in eight (20 per cent) and myringoplasty in three (7.5 per cent). The presence of<jats:italic>H pylori<\/jats:italic>was tested in all tympanosclerosis biopsies, but in only 26.9 per cent of biopsies from other forms of chronic otitis media. A statistically significant difference in<jats:italic>H pylori<\/jats:italic>presence was found (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.01).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002301_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This study represents a preliminary investigation of the association between<jats:italic>H pylori<\/jats:italic>and tympanosclerosis development.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111002301","type":"journal-article","created":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T09:29:48Z","timestamp":1315214988000},"page":"1121-1124","source":"Crossref","is-referenced-by-count":11,"title":["Could<i>Helicobacter pylori<\/i>play a role in the aetiopathogenesis of tympanosclerosis?"],"prefix":"10.1017","volume":"125","author":[{"given":"A","family":"Iriz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Eryilmaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Gocer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Acar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Boynuegri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Dursun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"S0022215111002301_ref20","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00005537-200304000-00018","article-title":"A possible role of Helicobacter pylori in chronic rhinosinusitis: a preliminary report","volume":"113","author":"Ozdek","year":"2003","journal-title":"Laryngoscope"},{"key":"S0022215111002301_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.12.009"},{"key":"S0022215111002301_ref17","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200206000-00004"},{"key":"S0022215111002301_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92894-L"},{"key":"S0022215111002301_ref14","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900305"},{"key":"S0022215111002301_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00004"},{"key":"S0022215111002301_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815ed115"},{"key":"S0022215111002301_ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.559"},{"key":"S0022215111002301_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/PL00007517"},{"key":"S0022215111002301_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00175993"},{"key":"S0022215111002301_ref5","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/s00405-001-0441-y","article-title":"Genetic predisposition for tympanosclerotic degeneration","volume":"259","author":"Koc","year":"2002","journal-title":"Eur Arch Otolaryngol"},{"key":"S0022215111002301_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000187049.66168.04"},{"key":"S0022215111002301_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816770ba"},{"key":"S0022215111002301_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400807"},{"key":"S0022215111002301_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000226293.49789.80"},{"key":"S0022215111002301_ref1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487209138189"},{"key":"S0022215111002301_ref15","first-page":"298","article-title":"Devolopment of tympanosclerosis: can predicting factors be identified?","volume":"18","author":"Fors\u00e9ni","year":"1997","journal-title":"Am J Otol"},{"key":"S0022215111002301_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00021"},{"key":"S0022215111002301_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000169046.31136.1a"},{"key":"S0022215111002301_ref21","article-title":"Is CLO test alone adequate to diagnose Campylobacter pylori?","volume":"83","author":"Dye","year":"1988","journal-title":"Am J Gastroenterol"},{"key":"S0022215111002301_ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.122701"}],"container-title":["The Journal of Laryngology &amp; 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