{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:16:32Z","timestamp":1760984192385},"reference-count":13,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T00:00:00Z","timestamp":1317600000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111002490_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate the effect of transoral laser microsurgery for early glottic cancer on subjective and objective vocal outcome measures.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002490_sec2\"><jats:title>Design:<\/jats:title><jats:p>Prospective cohort study.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002490_sec3\"><jats:title>Setting:<\/jats:title><jats:p>Tertiary care cancer centre.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002490_sec4\"><jats:title>Participants:<\/jats:title><jats:p>All patients scheduled for transoral laser microsurgery for untreated early primary glottic cancer over a 22-month period and offered voice assessment (31 patients; 19 tumour stage one, 12 tumour stage two).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002490_sec5\"><jats:title>Main outcome measures:<\/jats:title><jats:p>Fundamental frequency, maximum phonation time, calculated jitter, shimmer and subjective voice rating, analysed by tumour stage.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002490_sec6\"><jats:title>Results:<\/jats:title><jats:p>Tumour stage T<jats:sub>1<\/jats:sub> patients had significantly different fundamental frequencies and maximum phonation times at three months post-operatively, compared with pre-operative values; these differences resolved by 12 months. At 12 months, tumour stage T<jats:sub>2<\/jats:sub> patients had significantly shorter maximum phonation times, and all patients reported significantly worse subjective voice ratings, compared with pre-operative values.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002490_sec7\"><jats:title>Conclusion:<\/jats:title><jats:p>We found no change in fundamental frequency, jitter and shimmer, one year post-operatively. Maximum phonation time deteriorated but stage one patients appeared to compensate, whereas stage two patients did not. Resection size may be a factor. All patients reported significantly worse subjective voice ratings at one year. Aerodynamic and subjective voice measures appear most sensitive to change in this patient group.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111002490","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T05:29:16Z","timestamp":1317619756000},"page":"1251-1255","source":"Crossref","is-referenced-by-count":12,"title":["\u2018How does that sound?\u2019: objective and subjective voice outcomes following CO<sub>2<\/sub> laser resection for early glottic cancer"],"prefix":"10.1017","volume":"125","author":[{"given":"S E","family":"Lester","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M H","family":"Rigby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"MacLean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S M","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2011,10,3]]},"reference":[{"key":"S0022215111002490_ref13","doi-asserted-by":"publisher","DOI":"10.1044\/1058-0360.0603.66"},{"key":"S0022215111002490_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s004050000299"},{"key":"S0022215111002490_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(98)00058-9"},{"key":"S0022215111002490_ref2","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200903"},{"key":"S0022215111002490_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20659"},{"key":"S0022215111002490_ref5","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/hed.20625","article-title":"Quality of life and voice in patients after laser cordectomy for Tis and T1 glottic carcinomas","volume":"29","author":"Jong-Lyel","year":"2007","journal-title":"Head Neck"},{"key":"S0022215111002490_ref9","doi-asserted-by":"publisher","DOI":"10.1177\/000348940611500803"},{"key":"S0022215111002490_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00025"},{"key":"S0022215111002490_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0512-9"},{"key":"S0022215111002490_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0313-1"},{"key":"S0022215111002490_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0003489402111S1202"},{"key":"S0022215111002490_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.9.965"},{"key":"S0022215111002490_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21578"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215111002490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T23:14:10Z","timestamp":1556320450000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215111002490\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,3]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0022215111002490"],"URL":"https:\/\/doi.org\/10.1017\/s0022215111002490","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,3]]}}}