{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:06:32Z","timestamp":1784192792761,"version":"3.55.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T00:00:00Z","timestamp":1319760000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215111002921_sec1\"><jats:title>Objective:<\/jats:title><jats:p>The temporal bone may be the first involved site in cases of systemic disease, and may even present with acute, mastoiditis-like symptomatology. This study aimed to evaluate the incidence of such non-infectious \u2018acute mastoiditis\u2019 in children.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002921_sec2\"><jats:title>Materials and methods:<\/jats:title><jats:p>Retrospective chart review of 73 children admitted to a tertiary referral centre for acute mastoiditis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002921_sec3\"><jats:title>Results:<\/jats:title><jats:p>In 71 cases (97.3 per cent), an infectious basis was identified. In the majority of cases (33 of 73; 45 per cent), the responsible bacteria was <jats:italic>Streptococcus pneumoniae<\/jats:italic>. However, histopathological studies revealed a non-infectious underlying disease (myelocytic leukaemia or Langerhans' cell histiocytosis) in two atypical cases (2.7 per cent).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215111002921_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>\u2018Acute mastoiditis\u2019 of non-infectious aetiology is a rare but real threat for children, and a challenging diagnosis for otologists. A non-infectious basis should be suspected in every atypical, persistent or recurrent case of acute mastoiditis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215111002921","type":"journal-article","created":{"date-parts":[[2011,10,28]],"date-time":"2011-10-28T04:31:34Z","timestamp":1319776294000},"page":"244-248","source":"Crossref","is-referenced-by-count":8,"title":["Incidence of non-infectious \u2018acute mastoiditis\u2019 in children"],"prefix":"10.1017","volume":"126","author":[{"given":"G","family":"Kontorinis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Psarommatis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Karabinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z","family":"Iliodromiti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tsakanikos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2011,10,28]]},"reference":[{"key":"S0022215111002921_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-007-0549-1"},{"key":"S0022215111002921_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/BF02017656"},{"key":"S0022215111002921_ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197911000-00004"},{"key":"S0022215111002921_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedex.2007.10.004"},{"key":"S0022215111002921_ref1","doi-asserted-by":"publisher","DOI":"10.1590\/S0034-72992005000500015"},{"key":"S0022215111002921_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1945.00680040351005"},{"key":"S0022215111002921_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1993.01880130115018"},{"key":"S0022215111002921_ref4","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199401000-00011"},{"key":"S0022215111002921_ref16","first-page":"339","article-title":"Relapse of acute myeloblastic leukaemia presenting as temporal bone chloroma with facial nerve paralysis","volume":"4","author":"Wuillemin","year":"1993","journal-title":"Ann Oncol"},{"key":"S0022215111002921_ref8","first-page":"246","volume-title":"Leukemia","author":"Gunz","year":"1974"},{"key":"S0022215111002921_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00374-8"},{"key":"S0022215111002921_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(90)90005-C"},{"key":"S0022215111002921_ref14","first-page":"187","article-title":"Clinical presentation of acute mastoiditis in children","volume":"33","author":"Jiang","year":"2000","journal-title":"J Microbiol Immunol Infect"},{"key":"S0022215111002921_ref2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197309000-00010"},{"key":"S0022215111002921_ref15","first-page":"402","article-title":"An unusual cause of mastoiditis that evolved into multiple ring-enhancing intracerebral lesions in a person with HIV infection","volume":"17","author":"Casula","year":"2007","journal-title":"AIDS Read"},{"key":"S0022215111002921_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(03)00049-8"},{"key":"S0022215111002921_ref9","first-page":"19","volume-title":"Leukemia and Lymphoma in the Nervous System","author":"Pochedly","year":"1977"},{"key":"S0022215111002921_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/000348946907800215"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215111002921","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T21:26:02Z","timestamp":1556227562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215111002921\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10,28]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S0022215111002921"],"URL":"https:\/\/doi.org\/10.1017\/s0022215111002921","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10,28]]}}}