{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:52:20Z","timestamp":1790599940082,"version":"4.1.0"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221511100332X_sec1\"><jats:title>Background:<\/jats:title><jats:p>Traditionally, a 1-cm surgical resection margin is used for early oral tongue tumours.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511100332X_sec2\"><jats:title>Methods:<\/jats:title><jats:p>All tumour stage one (<jats:italic>n<\/jats:italic>\u00a0=\u00a065) and stage two (<jats:italic>n<\/jats:italic>\u00a0=\u00a013) oral tongue cancers treated between January 1999 and January 2009 were followed for a median of 38 months (minimum 12 months). The sites of close and involved margins were histologically reviewed.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511100332X_sec3\"><jats:title>Results:<\/jats:title><jats:p>Involved and close margins occurred in 14 and 55 per cent of cases, respectively. The number of involved <jats:italic>vs<\/jats:italic> clear or close margins was equivalent in tumour stage one (90 <jats:italic>vs<\/jats:italic> 82 per cent), node-negative (100 <jats:italic>vs<\/jats:italic> 84 per cent) and perineural or lymphovascular invasion (20 <jats:italic>vs<\/jats:italic> 21 per cent) cases. Close or involved margins were similarly likely to be posterior (59 per cent) as anterior (41 per cent, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.22), lateral (57 per cent) as medial (43 per cent, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.34), and mucosal (59 per cent) as deep (41 per cent, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.22). Local recurrence occurred in 28 per cent of cases at a median of 12 months, and was more likely in cases with involved (50 per cent) than clear or close margins (25 per cent, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.10). Disease-free survival was worse in involved margins cases (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.002).<\/jats:p><\/jats:sec><jats:sec id=\"S002221511100332X_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Involved margins are common in early tongue tumours, and are associated with increased local recurrence and worse survival. Close or involved margins occur in all directions and all tumour types. A wider margin may be justified.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221511100332x","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T13:29:22Z","timestamp":1326979762000},"page":"289-294","source":"Crossref","is-referenced-by-count":40,"title":["Are wider surgical margins needed for early oral tongue cancer?"],"prefix":"10.1017","volume":"126","author":[{"given":"T A","family":"Iseli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M J","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Guiney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Wiesenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C E","family":"Iseli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"S002221511100332X_ref10","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199301000-00012"},{"key":"S002221511100332X_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3656-4"},{"key":"S002221511100332X_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199707)19:4<281::AID-HED6>3.0.CO;2-X"},{"key":"S002221511100332X_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e328058670f"},{"key":"S002221511100332X_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21334"},{"key":"S002221511100332X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(98)80055-1"},{"key":"S002221511100332X_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000149687.90710.21"},{"key":"S002221511100332X_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200010000-00039"},{"key":"S002221511100332X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2005.06.008"},{"key":"S002221511100332X_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q"},{"key":"S002221511100332X_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20269"},{"key":"S002221511100332X_ref3","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20279"},{"key":"S002221511100332X_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21523"},{"key":"S002221511100332X_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20879"},{"key":"S002221511100332X_ref12","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1002\/hed.20789","article-title":"Involved margin of tongue cancer: the impact of tumor satellites on prognosis","volume":"30","author":"Yan","year":"2008","journal-title":"Head Neck"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221511100332X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,26]],"date-time":"2019-04-26T01:26:04Z","timestamp":1556241964000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221511100332X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["S002221511100332X"],"URL":"https:\/\/doi.org\/10.1017\/s002221511100332x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}