{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:22:31Z","timestamp":1793744551938,"version":"4.6.1"},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T00:00:00Z","timestamp":1330300800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112000102_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the effect of the Meniett<jats:sup>\u00ae<\/jats:sup> low-pressure generator on the subjective symptoms and audiovestibular disease markers of patients with unilateral Meni\u00e8re's disease unresponsive to betahistine treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000102_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Randomised, placebo-controlled, double-blinded, clinical trial at a tertiary referral centre. After ventilation tube placement, patients were randomised to the active treatment or placebo group. Monitoring comprised audiometry and air caloric testing and a vertigo diary (enabling calculation of vertigo and activity scores, and the number of vertigo days, vertigo-free days and sick days).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000102_sec3\"><jats:title>Results:<\/jats:title><jats:p>Sixty-eight patients completed the study. For the active treatment versus placebo group, the following pre- and post-treatment values, and significances for treatment effect comparisons, were respectively seen: cumulative vertigo scores, 22.47 and 15.97 <jats:italic>vs<\/jats:italic> 20.42 and 19.23 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.048); vertigo days, 6.5 and 4.08 <jats:italic>vs<\/jats:italic> 5.94 and 5.52 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.102); sick days, 3.08 and 0.78 <jats:italic>vs<\/jats:italic> 2.87 and 3.45 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041); vertigo-free days, 14.47 and 17.61 <jats:italic>vs<\/jats:italic> 15.48 and 17.58 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.362); activity score, 23.61 and 13.42 <jats:italic>vs<\/jats:italic> 24.68 and 20.23 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.078); low-tone hearing threshold, 49.15 and 53.18\u00a0dB nHL <jats:italic>vs<\/jats:italic> 41.66 and 46.10\u00a0dB nHL (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05); and slow phase velocity in response to caloric stimulation, 18.86 and 18.72 \u00b0\/second <jats:italic>vs<\/jats:italic> 14.97 and 15.95 \u00b0\/second, (<jats:italic>p<\/jats:italic>\u00a0&gt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000102_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Use of the Meniett<jats:sup>\u00ae<\/jats:sup> low-pressure generator improved patients' vertigo but not their hearing or vestibular function. This safe, minimally invasive treatment is recommended as second-line treatment for unilateral Meni\u00e8re's disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112000102","type":"journal-article","created":{"date-parts":[[2012,2,27]],"date-time":"2012-02-27T10:50:11Z","timestamp":1330339811000},"page":"356-362","source":"Crossref","is-referenced-by-count":38,"title":["Effect of transtympanic low-pressure therapy in patients with unilateral Meni\u00e8re's disease unresponsive to betahistine: a randomised, placebo-controlled, double-blinded, clinical trial"],"prefix":"10.1017","volume":"126","author":[{"given":"R","family":"G\u00fcrkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L B","family":"Filipe Mingas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Rader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Louza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Olzowy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,2,27]]},"reference":[{"key":"S0022215112000102_ref9","first-page":"726","article-title":"Immediate effects of middle ear pressure changes on the electrocochleographic recordings in patients with Meniere's disease: a clinical placebo-controlled study","volume":"18","author":"Densert","year":"1997","journal-title":"Am J Otol"},{"key":"S0022215112000102_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-009-1915-2"},{"key":"S0022215112000102_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-006-1512-6"},{"key":"S0022215112000102_ref3","doi-asserted-by":"publisher","DOI":"10.3109\/00016488609119424"},{"key":"S0022215112000102_ref1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2000.00374.x"},{"key":"S0022215112000102_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/AUD.0b013e3181734ed0"},{"key":"S0022215112000102_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.01.007"},{"key":"S0022215112000102_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200501000-00012"},{"key":"S0022215112000102_ref2","doi-asserted-by":"publisher","DOI":"10.3109\/00016487709128803"},{"key":"S0022215112000102_ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.6.718"},{"key":"S0022215112000102_ref10","doi-asserted-by":"publisher","DOI":"10.1080\/000164800454107"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112000102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T23:44:25Z","timestamp":1556235865000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112000102\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,27]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0022215112000102"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112000102","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,27]]}}}