{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T03:53:07Z","timestamp":1778039587605,"version":"3.51.4"},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T00:00:00Z","timestamp":1336089600000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112000485_sec1\"><jats:title>Background:<\/jats:title><jats:p>Little is known about the effects of macrolides on the cytokines and chemokines that modulate the function of eosinophils in nasal polyposis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000485_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Twenty-two non-allergic and 18 allergic patients with nasal polyps were administered clarithromycin 500\u00a0mg\/day (single oral dose) for eight weeks. We measured the nasal secretion levels of the T helper 2 (also known as Th2) cytokines interleukin 4, 5 and 6, the \u2018regulated on activation, normal T cell expressed and secreted\u2019 (also known as RANTES) chemokine, and the eosinophilic cationic protein, before and after treatment.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000485_sec3\"><jats:title>Results:<\/jats:title><jats:p>After clarithromycin treatment, we found reduced levels of the \u2018regulated on activation, normal T cell expressed and secreted\u2019 chemokine in samples from both non-allergic and allergic patients (<jats:italic>p &lt;<\/jats:italic> 0.05). Clarithromycin treatment decreased the levels of eosinophilic cationic protein only in non-allergic patients (<jats:italic>p &lt;<\/jats:italic> 0.05), and decreased the level of interleukin 6 only in allergic patients (<jats:italic>p &lt;<\/jats:italic> 0.05). Decreased levels of the \u2018regulated on activation, normal T cell expressed and secreted\u2019 chemokine were associated with a reduction in polyp size both in non-allergic and allergic patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000485_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Clarithromycin has a strong anti-inflammatory effect in nasal polyposis, but has different immunomodulatory effects in allergic and non-allergic nasal polyposis patients.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112000485","type":"journal-article","created":{"date-parts":[[2012,5,4]],"date-time":"2012-05-04T09:09:40Z","timestamp":1336122580000},"page":"495-502","source":"Crossref","is-referenced-by-count":22,"title":["Effect of long-term, low-dose clarithromycin on T helper 2 cytokines, eosinophilic cationic protein and the \u2018regulated on activation, normal T cell expressed and secreted\u2019 chemokine in the nasal secretions of patients with nasal polyposis"],"prefix":"10.1017","volume":"126","author":[{"given":"A","family":"Peri\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Vojvodi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Matkovi\u0107-Jo\u017ein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,5,4]]},"reference":[{"key":"S0022215112000485_ref31","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.8.945"},{"key":"S0022215112000485_ref30","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600951368"},{"key":"S0022215112000485_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1998.tb03767.x"},{"key":"S0022215112000485_ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2008.00848.x"},{"key":"S0022215112000485_ref24","doi-asserted-by":"publisher","DOI":"10.2500\/105065899782102791"},{"key":"S0022215112000485_ref23","first-page":"66","article-title":"A 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