{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:39Z","timestamp":1783486239688,"version":"3.55.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T00:00:00Z","timestamp":1337644800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112000722_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Amiodarone can induce severe hyperthyroidism that justifies its withdrawal and the introduction of antithyroid drugs. Continuing amiodarone use, failure to control hyperthyroidism and poor clinical progress may require thyroidectomy. This study aimed to evaluate patients\u2019 post-operative development and mid-term outcome after thyroidectomy for amiodarone-associated thyrotoxicosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000722_sec2\"><jats:title>Study design:<\/jats:title><jats:p>Prospective case series.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000722_sec3\"><jats:title>Setting:<\/jats:title><jats:p>Tertiary care centre.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000722_sec4\"><jats:title>Subjects and methods:<\/jats:title><jats:p>We prospectively collected cases of amiodarone-associated thyrotoxicosis requiring thyroidectomy due to failure of antithyroid treatment, despite amiodarone discontinuation. Post-thyroidectomy complications were compared immediately, 30 days and one year post-operatively, and also for scheduled versus emergency surgery cases.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000722_sec5\"><jats:title>Results:<\/jats:title><jats:p>Of 11 total cases, nine scheduled thyroidectomy cases had no morbidity after elective surgery. Two cases required emergency surgery for multiple organ failure and cardiac problems. Immediate post-operative complications (mostly haemodynamic) occurred in both cases (emergency<jats:italic>vs<\/jats:italic>routine surgery,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.018).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112000722_sec6\"><jats:title>Conclusion:<\/jats:title><jats:p>In such cases, pre-operative medical treatment is vital to limit peri- and post-operative complications, but surgery should not be delayed if the haemodynamic status deteriorates. Surgery, with careful anaesthesia, is the cornerstone of the treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112000722","type":"journal-article","created":{"date-parts":[[2012,5,22]],"date-time":"2012-05-22T10:20:10Z","timestamp":1337682010000},"page":"701-705","source":"Crossref","is-referenced-by-count":23,"title":["Total thyroidectomy for amiodarone-associated thyrotoxicosis: should surgery always be delayed for pre-operative medical preparation?"],"prefix":"10.1017","volume":"126","author":[{"given":"C","family":"Pierret","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J-P","family":"Tourtier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Pons","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Merat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Duverger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Perrier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,5,22]]},"reference":[{"key":"S0022215112000722_ref2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-1-199701010-00009"},{"key":"S0022215112000722_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199803000-00005"},{"key":"S0022215112000722_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0033-0620(89)90017-0"},{"key":"S0022215112000722_ref16","first-page":"1062","article-title":"Amiodarone-associated thyrotoxicosis (AAT): experience with surgical management","volume":"102","author":"Brennan","year":"1987","journal-title":"Surgery"},{"key":"S0022215112000722_ref15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2000.01816.x"},{"key":"S0022215112000722_ref7","first-page":"213","article-title":"Amiodarone-associated thyrotoxicosis. A review","volume":"33","author":"Piga","year":"2008","journal-title":"Minerva Endocrinol"},{"key":"S0022215112000722_ref12","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.61.713.249"},{"key":"S0022215112000722_ref17","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/PL00024613","article-title":"Surgical management of amiodarone associated thyrotoxicosis: too risky or too effective?","volume":"22","author":"Hamoir","year":"1998","journal-title":"World J Surg"},{"key":"S0022215112000722_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(91)90187-3"},{"key":"S0022215112000722_ref11","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.107047"},{"key":"S0022215112000722_ref18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/0310057X0102900104","article-title":"Anaesthesia for amiodarone-associated thyrotoxicosis: a case review","volume":"29","author":"Sutherland","year":"2001","journal-title":"Anaesth Intensive Care"},{"key":"S0022215112000722_ref6","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176453"},{"key":"S0022215112000722_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-004-7599-6"},{"key":"S0022215112000722_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)01590-0"},{"key":"S0022215112000722_ref1","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176471"},{"key":"S0022215112000722_ref10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1984.tb01212.x"},{"key":"S0022215112000722_ref3","first-page":"1","article-title":"Amiodarone and the thyroid","volume":"13","author":"Lombardi","year":"1990","journal-title":"Thyroid Today"},{"key":"S0022215112000722_ref8","first-page":"2930","article-title":"Treatment of amiodarone-associated thyrotoxicosis, a difficult challenge: results of prospective study","volume":"81","author":"Bartalena","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"S0022215112000722_ref19","first-page":"910","article-title":"Guidelines for perioperative cardiovascular evaluation for noncardiac surgery. Report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee on Perioperative Cardiovascular Evaluation for Noncardiac Surgery)","volume":"27","author":"Eagle","year":"1996","journal-title":"J Am Coll Cardiol"},{"key":"S0022215112000722_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/85.1.15"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112000722","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T18:34:36Z","timestamp":1713983676000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112000722\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,22]]},"references-count":20,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0022215112000722"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112000722","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,22]]}}}