{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:41:09Z","timestamp":1761986469119},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2012,6,29]],"date-time":"2012-06-29T00:00:00Z","timestamp":1340928000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112001193_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To evaluate the effect of meticulous endoscopic surgery, including opening of all involved sinus cells, on the subsequent symptoms and endoscopic findings of patients with massive nasal polyposis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112001193_sec2\"><jats:title>Study design and method:<\/jats:title><jats:p>One hundred patients with massive nasal polyposis resistant to medical treatment were selected. We documented each patient's demographic data, associated diseases, endoscopic findings, Lund\u2013Mackay score and Sino-Nasal Outcome Test 22 (SNOT22) symptom score. All patients were followed up for at least two years to evaluate any recurrence.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112001193_sec3\"><jats:title>Results:<\/jats:title><jats:p>Of the 100 patients, 20 per cent had a history of asthma and 27 per cent had undergone previous surgery. All underwent endoscopic sinus surgery. After two years of follow up, 8 per cent had recurrence requiring surgery. Recurrence was significantly associated with a history of asthma (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) and the histopathological presence of eosinophilia (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.014).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112001193_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Meticulous endoscopic opening of all involved sinus cells can be a safe and effective means of controlling massive nasal polyposis, with an acceptable recurrence rate.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112001193","type":"journal-article","created":{"date-parts":[[2012,7,18]],"date-time":"2012-07-18T10:04:32Z","timestamp":1342605872000},"page":"789-794","source":"Crossref","is-referenced-by-count":13,"title":["Meticulous endoscopic sinus surgery to prevent recurrence of massive nasal polyposis"],"prefix":"10.1017","volume":"126","author":[{"given":"S M S","family":"Hoseini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Saedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Aghazadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,6,29]]},"reference":[{"key":"S0022215112001193_ref12","first-page":"455","article-title":"Relationship between postoperative recurrence rate and eosinophil density of nasal polyps","volume":"119","author":"Tosun","year":"2010","journal-title":"Ann Otolaryngol"},{"key":"S0022215112001193_ref5","doi-asserted-by":"publisher","DOI":"10.1080\/00016480601053040"},{"key":"S0022215112001193_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000147933.14014.12"},{"key":"S0022215112001193_ref18","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/194589240501900404","article-title":"Revision functional endoscopic sinus surgery: objective and subjective surgical outcomes","volume":"19","author":"McMains","year":"2005","journal-title":"Am J Rhinol"},{"key":"S0022215112001193_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2004.01842.x"},{"key":"S0022215112001193_ref7","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105218"},{"key":"S0022215112001193_ref2","doi-asserted-by":"publisher","DOI":"10.2500\/ajr.2007.21.2978"},{"key":"S0022215112001193_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2006.01275.x"},{"key":"S0022215112001193_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-009-1146-x"},{"key":"S0022215112001193_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(03)01576-6"},{"key":"S0022215112001193_ref14","first-page":"233","article-title":"Extensive endoscopic sinus surgery: does this reduce the revision rate for nasal polyposis?","volume":"18","author":"Masterson","year":"2010","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"S0022215112001193_ref16","doi-asserted-by":"publisher","DOI":"10.1080\/00016480701827541"},{"key":"S0022215112001193_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000182825.82910.80"},{"key":"S0022215112001193_ref11","first-page":"188","article-title":"Revision endoscopic sinus surgery","volume":"39","author":"Cohen","year":"2009","journal-title":"Otolaryngol Clin North Am"},{"key":"S0022215112001193_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318058197a"},{"key":"S0022215112001193_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200406000-00025"},{"key":"S0022215112001193_ref6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/MLG.0b013e31802d6e4f","article-title":"Medium-term symptom outcomes after paranasal sinus surgery in children and young adults with cystic fibrosis","volume":"117","author":"Tilman","year":"2007","journal-title":"Laryngoscope"},{"key":"S0022215112001193_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200405000-00004"},{"key":"S0022215112001193_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.06.002"}],"container-title":["The Journal of Laryngology &amp; 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