{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:58:14Z","timestamp":1791197894491,"version":"4.1.0"},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2012,7,17]],"date-time":"2012-07-17T00:00:00Z","timestamp":1342483200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112001429_sec1\"><jats:title>Background:<\/jats:title><jats:p>Earlier studies have shown that individuals with thalidomide embryopathy can have skeletal deformities, ear and eye aberrations, and facial palsy. This study aimed to survey the frequency and characteristics of facial palsy in this group of individuals.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112001429_sec2\"><jats:title>Participants:<\/jats:title><jats:p>Thirty-one individuals with thalidomide embryopathy (age range, 45\u201347 years) and 25 healthy adults (age range, 41\u201356 years; mean age\u00a0\u00b1\u00a0standard deviation, 49\u00a0\u00b1\u00a04.2 years).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112001429_sec3\"><jats:title>Main outcome measures:<\/jats:title><jats:p>Voluntary facial movements, lip force and three-dimensional lip motion analysis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112001429_sec4\"><jats:title>Results and conclusion:<\/jats:title><jats:p>Four of the thalidomide embryopathy individuals (13 per cent) had congenital facial palsy. All four had eye aberrations, three had ear anomalies and one had a limb anomaly. Individuals with thalidomide embryopathy without a clinical diagnosis of facial impairment had significantly weaker lips and more restricted lip mobility than healthy controls. This study contributes to the overall knowledge of thalidomide embryopathy by adding a description of how facial expression can be affected in this condition.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112001429","type":"journal-article","created":{"date-parts":[[2012,8,15]],"date-time":"2012-08-15T11:17:04Z","timestamp":1345029424000},"page":"902-906","source":"Crossref","is-referenced-by-count":11,"title":["Facial palsy in individuals with thalidomide embryopathy: frequency and characteristics"],"prefix":"10.1017","volume":"126","author":[{"given":"L","family":"Sj\u00f6green","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Kiliaridis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,7,17]]},"reference":[{"key":"S0022215112001429_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00455-007-9143-y"},{"key":"S0022215112001429_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410200511"},{"key":"S0022215112001429_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30563"},{"key":"S0022215112001429_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.125.2.209"},{"key":"S0022215112001429_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2009.03.039"},{"key":"S0022215112001429_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1993.tb04997.x"},{"key":"S0022215112001429_ref16","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32179"},{"key":"S0022215112001429_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31769"},{"key":"S0022215112001429_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420380303"},{"key":"S0022215112001429_ref4","first-page":"100","article-title":"Congenital aberrant tearing: a re-look","volume":"106","author":"Miller","year":"2008","journal-title":"Trans Am Ophthalmol Soc"},{"key":"S0022215112001429_ref3","doi-asserted-by":"publisher","DOI":"10.1080\/00016350802307638"},{"key":"S0022215112001429_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70206-1"},{"key":"S0022215112001429_ref6","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/lary.20868","article-title":"Sunnybrook facial grading system: reliability and criteria for grading","volume":"120","author":"Neely","year":"2010","journal-title":"Laryngoscope"},{"key":"S0022215112001429_ref10","first-page":"47","article-title":"Ocular motility in thalidomide embryopathy","volume":"28","author":"Miller","year":"1991","journal-title":"J Pediatr Ophthalmol Strabismus"},{"key":"S0022215112001429_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2842.2010.02168.x"},{"key":"S0022215112001429_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10144"},{"key":"S0022215112001429_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(01)00532-8"},{"key":"S0022215112001429_ref14","first-page":"359","article-title":"Clinical manifestations in 17 Greek patients with Goldenhar syndrome","volume":"17","author":"Touliatou","year":"2006","journal-title":"Genet Couns"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112001429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,28]],"date-time":"2024-04-28T12:28:15Z","timestamp":1714307295000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112001429\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,17]]},"references-count":18,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0022215112001429"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112001429","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,17]]}}}