{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T13:52:47Z","timestamp":1782222767336,"version":"3.54.5"},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Carotid blow-out syndrome is one of the most devastating complications of head and neck carcinoma. It usually occurs as a post-operative complication or when the tumour compromises the vascular axis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results:<\/jats:title><jats:p>We report two patients who suffered carotid blow-out syndrome but who did not have the usual predisposing factors. Both patients had a pharyngolaryngeal carcinoma that was treated with chemoradiotherapy. Residual non-tumoural ulceration was seen along the lateral wall of the hypopharynx in both cases. This ulceration eventually reached the vascular axis, precipitating carotid rupture and death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Residual non-tumoural ulceration of the lateral wall of the hypopharynx after chemoradiotherapy should be considered with the utmost caution. Once persistence of the tumour is excluded, surgery is indicated to protect the vascular axis, in order to prevent carotid blow-out syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112001910","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T12:34:28Z","timestamp":1347366868000},"page":"1189-1191","source":"Crossref","is-referenced-by-count":10,"title":["Delayed carotid blow-out syndrome: a new complication of chemoradiotherapy treatment in pharyngolaryngeal carcinoma"],"prefix":"10.1017","volume":"126","author":[{"given":"E","family":"Esteller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"de Juan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Quer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"S0022215112001910_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2004.12.062"},{"key":"S0022215112001910_ref4","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1089\/jpm.2008.9901","article-title":"Endovascular carotid reconstruction in palliative head and neck cancer patients with threatened carotid blowout presents a beneficial supportive care measure","volume":"11","author":"Koutsimpelas","year":"2008","journal-title":"J Palliat Med"},{"key":"S0022215112001910_ref7","first-page":"975","article-title":"Preliminary experience with endovascular reconstruction for the management of carotid blowout syndrome","volume":"24","author":"Lesley","year":"2003","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0022215112001910_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20753"},{"key":"S0022215112001910_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.11.005"},{"key":"S0022215112001910_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0028-8"},{"key":"S0022215112001910_ref2","first-page":"843","article-title":"Endovascular therapy for the carotid blowout syndrome in head and neck surgical patients: diagnostic and managerial considerations","volume":"17","author":"Chaloupka","year":"1996","journal-title":"AJNR Am J Neuroradiol"},{"key":"S0022215112001910_ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000058030"},{"key":"S0022215112001910_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(01)73640-6"},{"key":"S0022215112001910_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2007.12.030"},{"key":"S0022215112001910_ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199510000-00015"},{"key":"S0022215112001910_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0775-3"},{"key":"S0022215112001910_ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S002221510011000X"},{"key":"S0022215112001910_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2007.11.003"},{"key":"S0022215112001910_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/jso.21157"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112001910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T21:58:10Z","timestamp":1556143090000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112001910\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0022215112001910"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112001910","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]}}}