{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:43:22Z","timestamp":1787996602608,"version":"build-2784847793"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2012,9,14]],"date-time":"2012-09-14T00:00:00Z","timestamp":1347580800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background:<\/jats:title><jats:p>Cisplatin, an effective therapeutic agent for various human cancers, has dose-limiting side effects of ototoxicity and nephrotoxicity. Cisplatin ototoxicity is thought to result from increased amounts of toxic free radicals or cell membrane changes leading to increased intracellular calcium content. <jats:italic>Ginkgo biloba<\/jats:italic> extract prevents lipid peroxidation, decreases intracellular free oxygen radical levels, regulates the cell membrane calcium transport mechanism and prevents cell death. This study aimed to investigate the protective effect of <jats:italic>Ginkgo biloba<\/jats:italic> extract against cisplatin-induced ototoxicity in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Twenty Wistar albino rats with normal hearing (confirmed by distortion product otoacoustic emission testing prior to cisplatin application) were randomly allocated to two groups. Both groups received a single intraperitoneal dose of cisplatin (12\u00a0mg\/kg). Group two also received daily intraperitoneal doses of <jats:italic>Ginkgo biloba<\/jats:italic> extract (100\u00a0mg\/kg) for 10 days. Distortion product otoacoustic emission measurements were repeated on days 10 and 17 and signal-to-noise ratios were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Compared with group one, group two had significantly better distortion product otoacoustic emission results at 3, 4, 6 and 8\u00a0kHz on days 10 and 17.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>These findings suggest that <jats:italic>Ginkgo biloba<\/jats:italic> extract protects the inner ear against cisplatin-induced ototoxicity.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112002046","type":"journal-article","created":{"date-parts":[[2012,9,15]],"date-time":"2012-09-15T00:28:43Z","timestamp":1347668923000},"page":"1097-1101","source":"Crossref","is-referenced-by-count":21,"title":["The protective effect of <i>Ginkgo biloba<\/i> extract against experimental cisplatin ototoxicity: animal research using distortion product otoacoustic emissions"],"prefix":"10.1017","volume":"126","author":[{"given":"B","family":"Cakil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F Suren","family":"Basar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Atmaca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S Kurnaz","family":"Cengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Tekat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Tanyeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2012,9,14]]},"reference":[{"key":"S0022215112002046_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb00277.x"},{"key":"S0022215112002046_ref25","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3180430163"},{"key":"S0022215112002046_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900226"},{"key":"S0022215112002046_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.09.015"},{"key":"S0022215112002046_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/BF00262741"},{"key":"S0022215112002046_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00009"},{"key":"S0022215112002046_ref14","doi-asserted-by":"publisher","DOI":"10.1121\/1.382104"},{"key":"S0022215112002046_ref21","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002434"},{"key":"S0022215112002046_ref8","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198312000-00007"},{"key":"S0022215112002046_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00059-9"},{"key":"S0022215112002046_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(02)00634-2"},{"key":"S0022215112002046_ref19","doi-asserted-by":"publisher","DOI":"10.1191\/0748233705th255oa"},{"key":"S0022215112002046_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2027"},{"key":"S0022215112002046_ref15","first-page":"497","volume-title":"Handbook of Clinical Audiology","author":"Prieve","year":"2009"},{"key":"S0022215112002046_ref16","first-page":"167","volume-title":"Contemporary Perspectives in Hearing Assessment","author":"Lonsbury-Martin","year":"1999"},{"key":"S0022215112002046_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00116-6"},{"key":"S0022215112002046_ref1","first-page":"93","volume-title":"Ototoxicity","author":"Roland","year":"2004"},{"key":"S0022215112002046_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0909-7"},{"key":"S0022215112002046_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200403000-00028"},{"key":"S0022215112002046_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31322-7"},{"key":"S0022215112002046_ref23","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079X.2001.280202.x"},{"key":"S0022215112002046_ref20","first-page":"344","volume-title":"Anatomy and Physiology of Hearing for Audiologists","author":"Rybak","year":"2008"},{"key":"S0022215112002046_ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000093776"},{"key":"S0022215112002046_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(01)00224-6"},{"key":"S0022215112002046_ref17","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i2.299"},{"key":"S0022215112002046_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.055"}],"container-title":["The Journal of Laryngology &amp; 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