{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T19:57:12Z","timestamp":1762459032713},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T00:00:00Z","timestamp":1353369600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112002381_sec1\"><jats:title>Introduction:<\/jats:title><jats:p>The recurrent laryngeal nerve can be injured during surgery. This study investigated recurrent laryngeal nerve reinnervation.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002381_sec2\"><jats:title>Objective:<\/jats:title><jats:p>To study the short-term effects of primary anastomosis of the recurrent laryngeal nerve, by laryngeal electromyography and histopathological analysis, in a rabbit model.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002381_sec3\"><jats:title>Method:<\/jats:title><jats:p>Twenty Zealand rabbits underwent either right recurrent laryngeal nerve (1) transection with excision of 1\u00a0cm or (2) transection and end-to-end primary anastomosis. Vocal fold movements, laryngeal electromyography results and histological changes were recorded.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002381_sec4\"><jats:title>Results:<\/jats:title><jats:p>Vocal fold analysis showed a paramedian vocal fold in both groups, with perceptible vibratory movements in group two. Electromyography revealed total denervation potentials in group one, but denervation and regeneration signs in group two. Histopathologically, hyperkeratosis and parakeratosis of the vocal fold mucosa were seen in group one, and signs of parakeratosis and hyperplasia in group two.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002381_sec5\"><jats:title>Conclusion:<\/jats:title><jats:p>Even under ideal conditions for primary recurrent laryngeal nerve anastomosis, a return to normal muscle function is unlikely. However, such anastomosis prevents muscle atrophy, and should be performed as soon as possible. The degree of nerve recovery is associated with the number, amplitude and myelination level of fibrils returning to the original motor end-plaque.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112002381","type":"journal-article","created":{"date-parts":[[2012,11,20]],"date-time":"2012-11-20T13:47:53Z","timestamp":1353419273000},"page":"48-53","source":"Crossref","is-referenced-by-count":4,"title":["Short-term laryngeal electromyography and histopathological findings after primary reconstruction of the inferior laryngeal nerve in rabbits: prospective study"],"prefix":"10.1017","volume":"127","author":[{"given":"A","family":"Dalgic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kandogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Koc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C Ahmet","family":"Kulan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Yagci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Engin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Aksoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Ziya","family":"Ozuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,11,20]]},"reference":[{"key":"S0022215112002381_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100083717"},{"key":"S0022215112002381_ref12","doi-asserted-by":"publisher","DOI":"10.1177\/000348947108000507"},{"key":"S0022215112002381_ref2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0030-6665(20)31988-5","article-title":"Functional anatomy of the larynx","volume":"17","author":"Meller","year":"1984","journal-title":"Otolaryngol Clin North Am"},{"key":"S0022215112002381_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010221"},{"key":"S0022215112002381_ref14","first-page":"837","volume-title":"Head and Neck Surgery \u2013 Otolaryngology","author":"Rosen","year":"2006"},{"key":"S0022215112002381_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/000348940411301106"},{"key":"S0022215112002381_ref31","first-page":"855","article-title":"The cause and evaluation of unilateral vocal cord paralysis","volume":"84","author":"Srirompotong","year":"2001","journal-title":"J Med Assoc Thai"},{"key":"S0022215112002381_ref18","first-page":"232","volume-title":"Neurolaryngology: Recent Advances","author":"Hirano","year":"1987"},{"key":"S0022215112002381_ref9","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196302000-00002"},{"key":"S0022215112002381_ref25","doi-asserted-by":"publisher","DOI":"10.1080\/01926230600695631"},{"key":"S0022215112002381_ref6","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199010000-00019"},{"key":"S0022215112002381_ref4","first-page":"19","volume-title":"Diseases of the Larynx","author":"Kaya","year":"2002"},{"key":"S0022215112002381_ref3","first-page":"478","volume-title":"Diseases of the Nose, Throat, Ear, Head and Neck","author":"Petcu","year":"1991"},{"key":"S0022215112002381_ref22","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000903"},{"key":"S0022215112002381_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(97)90095-8"},{"key":"S0022215112002381_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/000348946807700214"},{"key":"S0022215112002381_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5541011201"},{"key":"S0022215112002381_ref23","doi-asserted-by":"publisher","DOI":"10.1177\/000348949610501002"},{"key":"S0022215112002381_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110001003"},{"key":"S0022215112002381_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940811700810"},{"key":"S0022215112002381_ref20","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199206000-00012"},{"key":"S0022215112002381_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900405"},{"key":"S0022215112002381_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200012000-00006"},{"key":"S0022215112002381_ref5","first-page":"1113","article-title":"Glycoprotein CD44 expression in benign, premalignant and malignant epithelial lesions of the larynx: an immunohistochemical study including correlation with Rb, p53, Ki-67 and PCNA","volume":"14","author":"Ioachim","year":"1999","journal-title":"Histol Histopathol"},{"key":"S0022215112002381_ref21","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000102"},{"key":"S0022215112002381_ref17","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198209001-00001"},{"key":"S0022215112002381_ref28","first-page":"237","article-title":"Histopathology of vocal cord palsy from recurrent laryngeal nerve damage","volume":"19","author":"Quiney","year":"1990","journal-title":"J Otolaryngol"},{"key":"S0022215112002381_ref8","doi-asserted-by":"publisher","DOI":"10.1177\/019459988209000414"},{"key":"S0022215112002381_ref29","first-page":"60","article-title":"Recurrent laryngeal nerve paralysis: current knowledge and treatment","volume":"117","author":"Hartl","year":"2000","journal-title":"Ann Otolaryngol Chir Cervicofac"},{"key":"S0022215112002381_ref26","doi-asserted-by":"crossref","DOI":"10.1177\/014556130608500704","article-title":"Severe laryngeal hyperkeratosis secondary to laryngopharyngeal reflux","volume":"85","author":"Garcia","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"S0022215112002381_ref16","first-page":"425","article-title":"Clinical and experimental studies on recurrent laryngeal nerve paralysis. Part 1. Clinical studies (No. 3). Comparison of phonation ability between end-to-end anastomosis of severed unilateral recurrent laryngeal nerve","volume":"83","author":"Ushio","year":"1982","journal-title":"J Jpn Surg Soc"},{"key":"S0022215112002381_ref13","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100061120"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112002381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T18:22:22Z","timestamp":1643653342000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112002381\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,20]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0022215112002381"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112002381","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,20]]}}}