{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T21:22:34Z","timestamp":1648761754879},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112002605_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the long-term efficacy of a fixed-dose intratympanic gentamicin treatment regime in controlling unilateral M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002605_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Pfleiderer (1998) published two-year follow-up results for a series of 16 patients treated with a 4-day, 12-dose intratympanic gentamicin regime for unilateral M\u00e9ni\u00e8re's disease that was refractory to medical treatment. In 2010, a long-term telephone follow up (mean 17 years and 3 months) of this same cohort was conducted to determine long-term vertigo control. Of the 16 patients, 13 were eligible for the long-term follow up.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002605_sec3\"><jats:title>Results:<\/jats:title><jats:p>At 2 years' follow up, all 16 patients experienced substantial control of vertigo, with complete control achieved in 87 per cent of cases. At the long-term follow up, 9 of the 13 eligible patients were contactable, and all reported complete control of vertigo.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002605_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Fixed-dose intratympanic gentamicin controlled symptomatic unilateral M\u00e9ni\u00e8re's disease in both the short and long term.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112002605","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T14:19:56Z","timestamp":1354889996000},"page":"20-24","source":"Crossref","is-referenced-by-count":7,"title":["Intratympanic gentamicin treatment for unilateral M\u00e9ni\u00e8re's disease: long-term follow up of a proven regime"],"prefix":"10.1017","volume":"127","author":[{"given":"J","family":"Wasson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Upile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pfleiderer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,12,7]]},"reference":[{"key":"S0022215112002605_ref9","doi-asserted-by":"publisher","DOI":"10.2302\/kjm.35.36"},{"key":"S0022215112002605_ref1","first-page":"1","article-title":"Ablation therapy in the management of Meni\u00e8re's disease","volume":"132","author":"Schuknecht","year":"1957","journal-title":"Acta Otolaryngol Suppl"},{"key":"S0022215112002605_ref4","first-page":"18","article-title":"Chemical labyrinthectomy: local application of gentamicin for the treatment of unilateral Meni\u00e8re's disease","volume":"13","author":"Nedzelski","year":"1992","journal-title":"Am J Otol"},{"key":"S0022215112002605_ref7","first-page":"1462","article-title":"Committee on Hearing and Equilibrium. Report of Subcommittee on Equilibrium and its Measurement: Meniere's disease: criteria for diagnosis and evaluation of therapy for reporting","volume":"76","author":"Alford","year":"1972","journal-title":"Trans Am Acad Ophthalmol Otolaryngol"},{"key":"S0022215112002605_ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1998.00092.x"},{"key":"S0022215112002605_ref10","first-page":"83","article-title":"Does intratympanic gentamicin treatment for Meniere's disease cause complete vestibular ablation?","volume":"29","author":"Hone","year":"2000","journal-title":"J Otolaryngol"},{"key":"S0022215112002605_ref3","doi-asserted-by":"publisher","DOI":"10.1258\/0022215053419871"},{"key":"S0022215112002605_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200407000-00023"},{"key":"S0022215112002605_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31815aea05"},{"key":"S0022215112002605_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000149439.43478.24"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112002605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T20:28:04Z","timestamp":1556137684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112002605\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,7]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0022215112002605"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112002605","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,7]]}}}