{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T12:17:08Z","timestamp":1769516228244,"version":"3.49.0"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"S1","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112002654_sec1\"><jats:title>Background:<\/jats:title><jats:p><jats:italic>Streptococcus pneumoniae<\/jats:italic> is a frequent cause of acute mastoiditis. Despite the recent (2005) introduction of pneumococcal vaccination, mastoiditis incidence and severity may be increasing. This study aimed to assess the incidence, severity and microbiology of acute mastoiditis over an 11-year period.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002654_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Retrospective review of paediatric acute mastoiditis cases seen at our institution (2000\u20132010), comparing patients seen prior to vaccination introduction (period one, 2000\u20132004), around the time of vaccine introduction (period two, 2005\u20132007) and post-vaccination (period three, 2008\u20132010).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002654_sec3\"><jats:title>Results:<\/jats:title><jats:p>We reviewed 84 children. In periods one, two and three, respectively: mean annual case load was 8.4, 5 and 9 children; pneumococcal isolates were seen in 40.5, 6.7 and 29.6 per cent of cases; highest recorded fever was 38.6, 38.9 and 38.2\u00b0C and highest leukocyte count 18.9, 15.0 and 15.6\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l; incidence of intracranial complications was 11.9, 0 and 7.4 per cent; mean duration of intravenous antibiotics was 6.0, 4.1 and 4.2 days; proportion treated surgically was 71.4, 60.0 and 48.1 per cent; and mean length of in-patient stay shortened.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112002654_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Pneumococcal mastoiditis admission rates appeared to fall when vaccination was introduced, with concomitant reduction in overall mastoiditis incidence and intracranial complications; subsequently, however, admission rates rapidly returned to pre-vaccination 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