{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:17:17Z","timestamp":1759961837425},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T00:00:00Z","timestamp":1354838400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,1]]},"abstract":"Abstract<\/jats:title>Objective:<\/jats:title>To explore the diagnosis and treatment of carcinosarcoma of the larynx.<\/jats:p><\/jats:sec>Methods:<\/jats:title>Clinical information, including presentation, pathology, treatment and outcome, was obtained from a review of patient charts.<\/jats:p><\/jats:sec>Results:<\/jats:title>Seven male patients were confirmed pathologically to have had carcinosarcoma between 2003 and 2009 in our hospital. All patients underwent surgery: four total laryngectomies, two vertical partial laryngectomies, and one supracricoid partial laryngectomy-cricohyoidopexy. The mean follow up was 40.6 months. At the time of writing, six patients were alive and being followed; two of these suffered regional metastasis to the cervical lymphatic nodes and underwent radical neck dissection. One patient died of multiple distant metastases 60 months post-operatively.<\/jats:p><\/jats:sec>Conclusion:<\/jats:title>Carcinosarcoma of the larynx describes a biphasic tumour showing both carcinomatous and sarcomatous differentiation. It is extraordinarily rare and prone to metastasise to the cervical lymph nodes. Complete surgical resection of laryngeal primary lesions with wide margins and suitable neck dissection of cervical nodes is reasonable therapy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221511200285x","type":"journal-article","created":{"date-parts":[[2012,12,7]],"date-time":"2012-12-07T10:09:20Z","timestamp":1354874960000},"page":"100-103","source":"Crossref","is-referenced-by-count":11,"title":["True carcinosarcoma of the larynx"],"prefix":"10.1017","volume":"127","author":[{"given":"M","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L-M","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X-M","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S-Y","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2012,12,7]]},"reference":[{"key":"S002221511200285X_ref11","doi-asserted-by":"publisher","DOI":"10.1080\/0036554021000028070"},{"key":"S002221511200285X_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.9.1031"},{"key":"S002221511200285X_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20150"},{"key":"S002221511200285X_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199805000-00024"},{"key":"S002221511200285X_ref1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1177\/014556130608500516","article-title":"Supracricoid partial laryngectomy as a primary treatment for carcinosarcoma of the larynx","volume":"85","author":"Luna-Ortiz","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"S002221511200285X_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20939"},{"key":"S002221511200285X_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200202000-00002"},{"key":"S002221511200285X_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100118626"},{"key":"S002221511200285X_ref10","first-page":"192","article-title":"Carcinosarcoma of the larynx: immunohistochemical study, clinical considerations, therapeutic strategies [in Italian]","volume":"21","author":"Ianniello","year":"2001","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"S002221511200285X_ref4","doi-asserted-by":"publisher","DOI":"10.4103\/0022-3859.33864"},{"key":"S002221511200285X_ref6","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/014556130007900512","article-title":"Initial report of a case of carcinosarcoma of the supraglottis","volume":"79","author":"Ernster","year":"2000","journal-title":"Ear Nose Throat J"},{"key":"S002221511200285X_ref5","first-page":"118","article-title":"Carcinosarcomas: current perspectives and an historical review of nosological concepts","volume":"10","author":"Wick","year":"1993","journal-title":"Semin Diagn Pathol"}],"container-title":["The Journal of Laryngology & Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221511200285X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T20:15:16Z","timestamp":1562444116000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221511200285X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,7]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S002221511200285X"],"URL":"https:\/\/doi.org\/10.1017\/s002221511200285x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,7]]}}}