{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:57:07Z","timestamp":1790013427323,"version":"4.0.1"},"reference-count":38,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112003003_sec1\"><jats:title>Background:<\/jats:title><jats:p>Sore throat is a common condition associated with acute upper respiratory tract infection, and recurrent episodes of infection may result in chronic tonsillitis. The current UK and USA guidelines for tonsillectomy use the incidence of sore throat episodes as an indication for surgery. However, the mechanism of sore throat is poorly described in the literature.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112003003_sec2\"><jats:title>Objectives:<\/jats:title><jats:p>This review will provide basic information for the clinician regarding: the causes, pathophysiology and neurophysiology of sore throat; the mechanism of inflammation; and the role of transient receptor potential ion channels as nociceptors involved in sore throat. The review will present new ideas on the mechanism of ice therapy as an analgesic for post-tonsillectomy pain, and the role of vanilloid and cold receptors.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112003003","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T12:06:56Z","timestamp":1358251616000},"page":"227-232","source":"Crossref","is-referenced-by-count":34,"title":["A review on the mechanism of sore throat in tonsillitis"],"prefix":"10.1017","volume":"127","author":[{"given":"S","family":"Bathala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Eccles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"S0022215112003003_ref33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.152002699"},{"key":"S0022215112003003_ref31","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-0265-3_33"},{"key":"S0022215112003003_ref27","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/39807","article-title":"The capsaicin receptor: a heat-activated ion channel in the pain pathway","volume":"389","author":"Caterina","year":"1997","journal-title":"Nature"},{"key":"S0022215112003003_ref11","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125023"},{"key":"S0022215112003003_ref22","doi-asserted-by":"publisher","DOI":"10.3928\/00485718-20091124-04"},{"key":"S0022215112003003_ref21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.9.3245"},{"key":"S0022215112003003_ref20","first-page":"235","article-title":"The common cold","volume":"11","author":"Sperber","year":"1994","journal-title":"Infect Med"},{"key":"S0022215112003003_ref26","doi-asserted-by":"publisher","DOI":"10.1038\/224285a0"},{"key":"S0022215112003003_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80156-3"},{"key":"S0022215112003003_ref17","doi-asserted-by":"publisher","DOI":"10.3109\/00016489409126062"},{"key":"S0022215112003003_ref28","doi-asserted-by":"publisher","DOI":"10.2174\/157015906778019482"},{"key":"S0022215112003003_ref14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1964.03070210005001"},{"key":"S0022215112003003_ref32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.11.6155"},{"key":"S0022215112003003_ref10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.7883\/yoken.JJID.2004.271","article-title":"The rate of asymptomatic throat carriage of group A Streptococcus in school children and associated ASO titers in Duzce, Turkey","volume":"57","author":"Ozturk","year":"2004","journal-title":"Jpn J Infect Dis"},{"key":"S0022215112003003_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)01059-2"},{"key":"S0022215112003003_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0036-4_4"},{"key":"S0022215112003003_ref35","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-4637.2003.03019.x"},{"key":"S0022215112003003_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70270-X"},{"key":"S0022215112003003_ref25","doi-asserted-by":"publisher","DOI":"10.1213\/01.ane.0000266440.62424.f1"},{"key":"S0022215112003003_ref7","first-page":"1","volume-title":"Viral and Other Infections of the Human Respiratory Tract","author":"Johnston","year":"1996"},{"key":"S0022215112003003_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2011.07.002"},{"key":"S0022215112003003_ref12","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125024"},{"key":"S0022215112003003_ref16","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-67"},{"key":"S0022215112003003_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90178-8"},{"key":"S0022215112003003_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0036-4_10"},{"key":"S0022215112003003_ref1","volume-title":"Management of Sore Throat and Indications for Tonsillectomy. 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