{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T07:37:57Z","timestamp":1758267477335},"reference-count":10,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T00:00:00Z","timestamp":1358208000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215112003015_sec1\"><jats:title>Background:<\/jats:title><jats:p>Ceruminous mucoepidermoid carcinoma of the external auditory canal is extremely rare. This paper highlights the impact of concurrent chemoradiotherapy on the outcomes of this disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112003015_sec2\"><jats:title>Case report:<\/jats:title><jats:p>A 47-year-old female presented with a 2-month history of otalgia and a mass in her right ear. Biopsy revealed high grade ceruminous mucoepidermoid carcinoma. She underwent surgical excision of the right external auditory canal and right upper neck dissection. Pathological analysis of tumour\u2013node\u2013metastasis staging revealed a T<jats:sub>2<\/jats:sub> N<jats:sub>0<\/jats:sub> (stage II) tumour. One year later, computed tomography scanning of the temporal bone showed tumour recurrence. Biopsy revealed recurrent ceruminous mucoepidermoid carcinoma. The patient underwent salvage resection. Pathology revealed that the tumour was diffusely invading nearby structures, with perineural invasion, lymphatic spread and extracapsular extension. Pathological analysis of tumour\u2013node\u2013metastasis staging revealed a T<jats:sub>3<\/jats:sub> N<jats:sub>1<\/jats:sub> M<jats:sub>0<\/jats:sub> (recurrent stage IV) tumour.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112003015_sec8\"><jats:title>Results:<\/jats:title><jats:p>The patient subsequently received concurrent chemoradiotherapy. There was no evidence of disease at 37 months' follow up.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215112003015_sec3\"><jats:title>Conclusion:<\/jats:title><jats:p>The trimodality approach, using surgery plus concurrent chemoradiotherapy, provided reasonable loco-regional control with tolerable toxicity. Further detailed case reports are warranted to optimise the management of this rare malignancy.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215112003015","type":"journal-article","created":{"date-parts":[[2013,1,15]],"date-time":"2013-01-15T07:07:37Z","timestamp":1358233657000},"page":"203-206","source":"Crossref","is-referenced-by-count":10,"title":["Trimodality approach for ceruminous mucoepidermoid carcinoma of the external auditory canal"],"prefix":"10.1017","volume":"127","author":[{"given":"W F","family":"Mourad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K S","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Shourbaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L B","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,1,15]]},"reference":[{"key":"S0022215112003015_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(03)00056-5"},{"key":"S0022215112003015_ref7","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-825804"},{"key":"S0022215112003015_ref8","doi-asserted-by":"publisher","DOI":"10.1080\/00016480600818120"},{"key":"S0022215112003015_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0095-9"},{"key":"S0022215112003015_ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200403000-00003"},{"key":"S0022215112003015_ref2","volume-title":"Atlas of Head and Neck Pathology","author":"Wenig","year":"2007"},{"key":"S0022215112003015_ref3","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197710000-00001"},{"key":"S0022215112003015_ref4","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198702000-00006"},{"key":"S0022215112003015_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2007.05.003"},{"key":"S0022215112003015_ref10","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900909"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215112003015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T15:52:31Z","timestamp":1556121151000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215112003015\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S0022215112003015"],"URL":"https:\/\/doi.org\/10.1017\/s0022215112003015","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}