{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:15:16Z","timestamp":1778278516955,"version":"3.51.4"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T00:00:00Z","timestamp":1362009600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113000315_sec1\"><jats:title>Background:<\/jats:title><jats:p>Petrous apex aspergillosis is an uncommon and dangerous condition, with only four previously reported cases. As with other forms of petrous apicitis, the clinical symptoms are often non-specific and this contributes to diagnostic delay. This paper presents the first reported case of<jats:italic>Aspergillus<\/jats:italic>petrous apicitis associated with an intracranial or nasopharyngeal abscess.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000315_sec2\"><jats:title>Case report:<\/jats:title><jats:p>A 72-year-old man with chronic otorrhoea developed neuralgic headaches and progressive lower cranial nerve palsies despite antibiotic therapy. Imaging revealed petrous apicitis, a temporal lobe abscess and nasopharyngeal abscess. Analysis of biopsy tissue indicated invasive aspergillosis. The patient recovered on a protracted course of voriconazole in addition to medium-term antibiotic therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000315_sec3\"><jats:title>Conclusion:<\/jats:title><jats:p>Invasive fungal disease should be considered early in the course of skull base osteomyelitis that is clinically unresponsive to empirical broad spectrum antibiotics. This paper highlights the role of tissue biopsy in diagnosis, and the efficacy of voriconazole therapy without the need for radical surgery.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113000315","type":"journal-article","created":{"date-parts":[[2013,2,28]],"date-time":"2013-02-28T21:39:57Z","timestamp":1362087597000},"page":"404-407","source":"Crossref","is-referenced-by-count":23,"title":["<i>Aspergillus<\/i>petrous apicitis associated with cerebral and peritubular abscesses in an immunocompetent man"],"prefix":"10.1017","volume":"127","author":[{"given":"Y M","family":"Bhatt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Pahade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,2,28]]},"reference":[{"key":"S0022215113000315_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215109992507"},{"key":"S0022215113000315_ref20","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2165"},{"key":"S0022215113000315_ref19","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01220-08"},{"key":"S0022215113000315_ref12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.4103\/0028-3886.35689","article-title":"Craniocerebral aspergillosis in immunocompetent hosts: surgical perspective","volume":"55","author":"Shamim","year":"2007","journal-title":"Neurol India"},{"key":"S0022215113000315_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03231.x"},{"key":"S0022215113000315_ref9","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/71475327"},{"key":"S0022215113000315_ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1246229"},{"key":"S0022215113000315_ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-008-0877-4"},{"key":"S0022215113000315_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(97)90043-0"},{"key":"S0022215113000315_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200603"},{"key":"S0022215113000315_ref14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"S0022215113000315_ref10","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1115325"},{"key":"S0022215113000315_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3180536721"},{"key":"S0022215113000315_ref4","doi-asserted-by":"publisher","DOI":"10.1086\/513943"},{"key":"S0022215113000315_ref18","doi-asserted-by":"publisher","DOI":"10.1086\/424662"},{"key":"S0022215113000315_ref5","doi-asserted-by":"publisher","DOI":"10.1086\/592255"},{"key":"S0022215113000315_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1992.tb01013.x"},{"key":"S0022215113000315_ref13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.47102\/annals-acadmedsg.V37N9p783","article-title":"Intracranial aspergilloma in immunocompetent patients successfully treated with radical surgical intervention and antifungal therapy: case series","volume":"37","author":"Srinivasan","year":"2008","journal-title":"Ann Acad Med Singapore"},{"key":"S0022215113000315_ref16","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-870595"},{"key":"S0022215113000315_ref17","doi-asserted-by":"publisher","DOI":"10.1086\/324620"},{"key":"S0022215113000315_ref15","doi-asserted-by":"publisher","DOI":"10.1086\/525258"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113000315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T16:38:21Z","timestamp":1715013501000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113000315\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,28]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["S0022215113000315"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113000315","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,28]]}}}