{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T05:14:08Z","timestamp":1772774048575,"version":"3.50.1"},"reference-count":12,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T00:00:00Z","timestamp":1364860800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113000492_sec1\"><jats:title>Background and objectives:<\/jats:title><jats:p>There is currently little published guidance on the management of anticoagulant and antiplatelet medication in patients admitted with epistaxis. The routine practice of withholding such medication in an attempt to control the epistaxis is common in the UK. However, this practice is not evidence-based, is often unnecessary, and can be associated with significant morbidity. This study introduces a treatment algorithm for oral anticoagulant and antiplatelet therapy in epistaxis patients, validated through a completed audit cycle.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000492_sec2\"><jats:title>Methods:<\/jats:title><jats:p>One hundred patients admitted with epistaxis to the University Hospital Southampton NHS Foundation Trust were studied via a two-audit cycle covering the implementation of a new treatment algorithm formulated jointly by the otolaryngology and haematology departments.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000492_sec3\"><jats:title>Results:<\/jats:title><jats:p>On admission, 58 per cent of patients were taking some form of anticoagulant or antiplatelet medication. The number of patients having such medication withheld decreased significantly between the two audits, for all drugs studied (i.e. aspirin, clopidogrel and warfarin). There was no significant increase in re-bleeding or re-admission rates between the audits.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000492_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Implementation of this treatment algorithm would help standardise management for epistaxis patients taking anticoagulant or antiplatelet drugs, and should reduce morbidity associated with unnecessary routine discontinuation of such medication.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113000492","type":"journal-article","created":{"date-parts":[[2013,4,2]],"date-time":"2013-04-02T04:53:08Z","timestamp":1364878388000},"page":"483-488","source":"Crossref","is-referenced-by-count":29,"title":["Treatment algorithm for oral anticoagulant and antiplatelet therapy in epistaxis patients"],"prefix":"10.1017","volume":"127","author":[{"given":"T C","family":"Biggs","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Baruah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Mainwaring","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P G","family":"Harries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Salib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,4,2]]},"reference":[{"key":"S0022215113000492_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00101-007-1171-3"},{"key":"S0022215113000492_ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archinternmed.2010.407"},{"key":"S0022215113000492_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2011.00713.x"},{"key":"S0022215113000492_ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890010051009"},{"key":"S0022215113000492_ref9","doi-asserted-by":"publisher","DOI":"10.1057\/pt.2010.29"},{"key":"S0022215113000492_ref7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1001\/archinte.1994.00420130036007","article-title":"Risk factors for stroke and efficacy of antithrombotic therapy in atrial fibrillation. Analysis of pooled data from five randomized controlled trials","volume":"154","author":"Laupacis","year":"1994","journal-title":"Arch Intern Med"},{"key":"S0022215113000492_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110001921"},{"key":"S0022215113000492_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-010-0349-x"},{"key":"S0022215113000492_ref5","first-page":"312","article-title":"The incidence of bleeding complications associated with warfarin treatment in general practice in the United Kingdom","volume":"53","author":"Hollowell","year":"2003","journal-title":"Brit J Gen Pract"},{"key":"S0022215113000492_ref6","unstructured":"NHS National Institute for Health and Clinical Excellence: Atrial fibrillation (CG36). In: http:\/\/guidance.nice.org.uk\/CG36 [5 January 2010]"},{"key":"S0022215113000492_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1996.00440210043004"},{"key":"S0022215113000492_ref11","first-page":"92","article-title":"Epistaxis and oral anticoagulant therapy","volume":"42","author":"Choudhury","year":"2004","journal-title":"Rhinology"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113000492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T18:09:52Z","timestamp":1556042992000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113000492\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,2]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0022215113000492"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113000492","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,2]]}}}