{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:19:27Z","timestamp":1791476367944,"version":"4.3.4"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T00:00:00Z","timestamp":1365984000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221511300073X_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate endoscopic staging, and nitric oxide levels in the polyp tissue, in patients with nasal polyposis undergoing glucocorticoid therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511300073X_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Nasal polyposis was evaluated using endoscopic staging and measurement of polyp tissue nitric oxide levels (chemiluminescence method). Forty-five nasal polyposis patients received either nasal therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), oral therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a015) or combined therapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a015). Pre-treatment and post-treatment staging and nitric oxide levels were evaluated.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511300073X_sec3\"><jats:title>Results:<\/jats:title><jats:p>Endoscopic grading indicated significant post-treatment staging improvements in the oral (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) and combined (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.016) groups. Post-treatment staging differed significantly between the three groups (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.041), with greater improvements in the oral and combined groups. All groups showed significantly lower post-treatment nitric oxide levels, compared with baseline, but post-treatment levels did not differ significantly between groups. A significant association was found between treatment response and nitric oxide level alteration.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511300073X_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This study demonstrates the favourable effects of glucocorticoids on nasal polyposis, and alteration in nitric oxide tissue levels post-treatment. Nitric oxide level in nasal polyp tissue could be an indicator of treatment response, and may aid surgical decision-making by detecting cases that probably will not respond to medical treatment.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221511300073x","type":"journal-article","created":{"date-parts":[[2013,4,15]],"date-time":"2013-04-15T16:50:25Z","timestamp":1366044625000},"page":"584-589","source":"Crossref","is-referenced-by-count":12,"title":["Effect of glucocorticoids on nasal polyposis, with detection of inflammatory response by measurement of nitric oxide levels in nasal polyp tissue"],"prefix":"10.1017","volume":"127","author":[{"given":"T","family":"B\u00fclb\u00fcl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6 G\u00fcm\u00fc\u015ftekin","family":"B\u00fclb\u00fcl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"G\u00fc\u00e7l\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Serpil","family":"Bilsel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S \u00d6nal","family":"G\u00fcrsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,4,15]]},"reference":[{"key":"S002221511300073X_ref11","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.10.947"},{"key":"S002221511300073X_ref15","first-page":"90","article-title":"Preoperative systemic steroid therapy and results in sinonasal polyposis [in Turkish]","volume":"4","author":"Karata\u015f","year":"2004","journal-title":"T\u00fcrkiye Klinikleri J ENT"},{"key":"S002221511300073X_ref8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.153.2.8564139"},{"key":"S002221511300073X_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00020840-200402000-00009"},{"key":"S002221511300073X_ref21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.96.09020202"},{"key":"S002221511300073X_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-004-0893-y"},{"key":"S002221511300073X_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01745.x"},{"key":"S002221511300073X_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31101-0"},{"key":"S002221511300073X_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-11412-0_3"},{"key":"S002221511300073X_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-11412-0_2"},{"key":"S002221511300073X_ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1998.00215.x"},{"key":"S002221511300073X_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD005232.pub2"},{"key":"S002221511300073X_ref6","doi-asserted-by":"publisher","DOI":"10.1097\/MOO.0b013e3282f1c7d0"},{"key":"S002221511300073X_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00130832-200502000-00007"},{"key":"S002221511300073X_ref13","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.116428"},{"key":"S002221511300073X_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/ar.20782"},{"key":"S002221511300073X_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.05.628"},{"key":"S002221511300073X_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-006-6111-1"},{"key":"S002221511300073X_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(02)00405-6"},{"key":"S002221511300073X_ref18","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v120.a88844"},{"key":"S002221511300073X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/S0385-8146(03)00051-8"},{"key":"S002221511300073X_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2005.00725.x"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S002221511300073X","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T21:39:02Z","timestamp":1556055542000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S002221511300073X\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,15]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S002221511300073X"],"URL":"https:\/\/doi.org\/10.1017\/s002221511300073x","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,15]]}}}