{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T15:58:05Z","timestamp":1760975885507},"reference-count":16,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113000765_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To introduce the application of confocal endomicroscopy during microlaryngoscopy, to enable intra-operative evaluation of human laryngeal epithelium.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000765_sec2\"><jats:title>Methods:<\/jats:title><jats:p>A rigid endoscope was connected to the scanner head of a Heidelberg Retina Tomograph II confocal laser scanning system via an adapter. The endoscope was gently placed on the surface of a vocal fold through a laryngoscope during microlaryngoscopy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000765_sec3\"><jats:title>Results:<\/jats:title><jats:p>The application of confocal endomicroscopy using a rigid endoscope enabled technical improvements (i.e. improved image quality, automatic volume scan, and reduced tissue pressure due to the presence of a perforation plate with central hole at the end of the endoscope) which permitted greater sensitivity and improved handling. Confocal endomicroscopy provided good quality,<jats:italic>in vivo<\/jats:italic>, en-face images and enabled an assessment of laryngeal epithelium volume.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113000765_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>This method enables the surgeon to monitor epithelial changes in pre-malignant lesions. The combination of confocal endomicroscopy together with optical coherence tomography (as a complementary technique that provides optical cross-sections) should be further explored in a formal clinicopathological study.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113000765","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T14:12:27Z","timestamp":1366726347000},"page":"599-604","source":"Crossref","is-referenced-by-count":10,"title":["Intra-operative application of confocal endomicroscopy using a rigid endoscope"],"prefix":"10.1017","volume":"127","author":[{"given":"T","family":"Just","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H W","family":"Pau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"S0022215113000765_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-007-1619-4"},{"key":"S0022215113000765_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-011-2423-8"},{"key":"S0022215113000765_ref16","doi-asserted-by":"publisher","DOI":"10.1038\/nm1692"},{"key":"S0022215113000765_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1991.tb01976.x"},{"key":"S0022215113000765_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200301000-00013"},{"key":"S0022215113000765_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21057"},{"key":"S0022215113000765_ref13","first-page":"177","volume-title":"Head and Neck Tumors","author":"Barnes","year":"2005"},{"key":"S0022215113000765_ref10","doi-asserted-by":"publisher","DOI":"10.1117\/12.886959"},{"key":"S0022215113000765_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.2.147"},{"key":"S0022215113000765_ref1","volume-title":"Krebs in Deutschland 2005\/2006","year":"2010"},{"key":"S0022215113000765_ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s00106-011-2428-3"},{"key":"S0022215113000765_ref7","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000217529.53079.59"},{"key":"S0022215113000765_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/000348949510400501"},{"key":"S0022215113000765_ref8","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966465"},{"key":"S0022215113000765_ref11","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1111\/j.1600-0714.2009.00841.x","article-title":"Rigid confocal endoscopy for in vivo imaging of experimental oral squamous intra-epithelial lesions","volume":"39","author":"Farahati","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"S0022215113000765_ref12","doi-asserted-by":"publisher","DOI":"10.1117\/12.921265"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113000765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,9]],"date-time":"2024-05-09T11:37:26Z","timestamp":1715254646000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113000765\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,23]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0022215113000765"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113000765","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,23]]}}}