{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:38:16Z","timestamp":1788950296918,"version":"build-2803163510"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T00:00:00Z","timestamp":1370476800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113001217_sec1\"><jats:title>Background and objectives:<\/jats:title><jats:p>The head and neck region is the second most frequent anatomical site of extranodal lymphomas. These tumours affect many individuals worldwide, justifying epidemiological studies in different countries. This study evaluated the characteristics, treatments and prognostic factors for non-Hodgkin's lymphoma of the head and neck in Chinese patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001217_sec2\"><jats:title>Method:<\/jats:title><jats:p>The clinical manifestations, clinicopathological characteristics, multidisciplinary treatment and prognostic factors for 102 patients with extranodal non-Hodgkin's lymphoma of the head and neck were analysed retrospectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001217_sec3\"><jats:title>Result:<\/jats:title><jats:p>The tonsil was the most commonly involved primary site, followed by the nasal cavity. The most common histological subtype was diffuse large B-cell lymphoma, followed by natural killer T-cell lymphoma. Patients receiving a combination of rituximab and chemotherapy did better than those receiving chemotherapy alone. Prognosis was significantly associated with both International Prognostic Index and histological subtype; the former was especially strongly associated with poor survival.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001217_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>In this group of Chinese patients, diffuse large B-cell lymphoma was the most common pathological subtype, but the incidence of T-cell lymphomas was higher than that reported in the USA. Combined rituximab and chemotherapy led to better outcomes than chemotherapy alone. Prognosis depended on both International Prognostic Index and histological subtype.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113001217","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T07:17:29Z","timestamp":1370503049000},"page":"699-704","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics and prognostic factors for head and neck non-Hodgkin's lymphoma in Chinese patients"],"prefix":"10.1017","volume":"127","author":[{"given":"J","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C-P","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-F","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-L","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,6,6]]},"reference":[{"key":"S0022215113001217_ref13","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"S0022215113001217_ref9","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500531682"},{"key":"S0022215113001217_ref32","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJM199309303291402","article-title":"A predictive model for aggressive non-Hodgkin's lymphoma: the International Non-Hodgkin's Lymphoma Prognostic Factors Project","volume":"329","author":"Shipp","year":"1993","journal-title":"N Engl J Med"},{"key":"S0022215113001217_ref11","first-page":"43","article-title":"The staging of non Hodgkin's lymphomas","volume":"17","author":"Moormeier","year":"1990","journal-title":"Semin Oncol"},{"key":"S0022215113001217_ref23","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.1384"},{"key":"S0022215113001217_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(90)90002-M"},{"key":"S0022215113001217_ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000227097"},{"key":"S0022215113001217_ref1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.43.1.7"},{"key":"S0022215113001217_ref15","doi-asserted-by":"publisher","DOI":"10.1080\/07357900701805686"},{"key":"S0022215113001217_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199601000-00012"},{"key":"S0022215113001217_ref14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1177\/014556130608501014","article-title":"Malignancy in asymmetrical but otherwise normal palatine tonsils","volume":"85","author":"Oluwasanmi","year":"2006","journal-title":"Ear Nose Throat J"},{"key":"S0022215113001217_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2008.05.011"},{"key":"S0022215113001217_ref29","doi-asserted-by":"publisher","DOI":"10.1080\/10428190127500"},{"key":"S0022215113001217_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(03)00182-X"},{"key":"S0022215113001217_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5.suppl_1.S19"},{"key":"S0022215113001217_ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nm0102-68"},{"key":"S0022215113001217_ref19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.3429"},{"key":"S0022215113001217_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910440112"},{"key":"S0022215113001217_ref31","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705244"},{"key":"S0022215113001217_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.07.002"},{"key":"S0022215113001217_ref18","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.3146"},{"key":"S0022215113001217_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900120068011"},{"key":"S0022215113001217_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2010.03.029"},{"key":"S0022215113001217_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2005.09.020"},{"key":"S0022215113001217_ref25","first-page":"55","article-title":"Characteristics of nasal T\/NK-cell lymphoma among Brazilians","volume":"49","author":"Altemani","year":"2002","journal-title":"Neoplasma"},{"key":"S0022215113001217_ref30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05651.x"},{"key":"S0022215113001217_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2004.03.028"},{"key":"S0022215113001217_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(85)90158-0"},{"key":"S0022215113001217_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200109000-00013"},{"key":"S0022215113001217_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19960515)77:10<2137::AID-CNCR27>3.0.CO;2-V"},{"key":"S0022215113001217_ref33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.03771.x"},{"key":"S0022215113001217_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<768::AID-CNCR2820560412>3.0.CO;2-W"},{"key":"S0022215113001217_ref26","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200011000-00006"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113001217","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,14]],"date-time":"2019-07-14T16:26:02Z","timestamp":1563121562000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113001217\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,6]]},"references-count":33,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["S0022215113001217"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113001217","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,6]]}}}