{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T21:44:01Z","timestamp":1694727841187},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113001254_sec1\"><jats:title>Background:<\/jats:title><jats:p>The role of total thyroidectomy in the management of patients with Graves' disease remains controversial. However, there is increasing evidence to support the role of the procedure as a safe and definitive treatment for Graves' disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001254_sec2\"><jats:title>Method:<\/jats:title><jats:p>Patients were identified from a prospective thyroid database of the multidisciplinary thyroid clinic at Hull Royal Infirmary. All case notes were independently reviewed to confirm the data held on the database.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001254_sec3\"><jats:title>Results:<\/jats:title><jats:p>Over a 7-year period, the senior author has performed 206 total thyroidectomies for Graves' disease. The incidence of temporary recurrent laryngeal nerve palsy and hypoparathyroidism was 3.4 per cent and 24 per cent respectively. There was one case of permanent unilateral recurrent laryngeal nerve palsy, and 3.9 per cent of patients developed permanent hypoparathyroidism. There has been no relapse of thyrotoxicosis.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001254_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>In the context of a multidisciplinary thyroid clinic, total thyroidectomy should be offered as a safe and effective first-line treatment option for Graves' disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113001254","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T08:40:25Z","timestamp":1371112825000},"page":"681-684","source":"Crossref","is-referenced-by-count":5,"title":["Total thyroidectomy for safe and definitive management of Graves' disease"],"prefix":"10.1017","volume":"127","author":[{"given":"A","family":"Prasai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Nix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Aye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Atkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"England","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,6,13]]},"reference":[{"key":"S0022215113001254_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2006.02.031"},{"key":"S0022215113001254_ref16","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2006.16.593"},{"key":"S0022215113001254_ref21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199803123381103"},{"key":"S0022215113001254_ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-6-1518"},{"key":"S0022215113001254_ref4","first-page":"3","article-title":"The management of hyperthyroidism due to Graves' disease in Europe in 1986. 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