{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:35:44Z","timestamp":1791585344339,"version":"4.3.4"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T00:00:00Z","timestamp":1374105600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113001266_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the rate of spontaneous tumour shrinkage in a group of patients with sporadic vestibular schwannoma managed with a \u2018wait and scan\u2019 approach.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001266_sec2\"><jats:title>Patients:<\/jats:title><jats:p>All patients with a unilateral cerebello-pontine angle tumour resembling a vestibular schwannoma were registered prospectively in a national database in Denmark. Patients registered with tumour shrinkage were identified and all computed tomography and magnetic resonance imaging scans retrieved, re-evaluated and related to the clinical data.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001266_sec3\"><jats:title>Results:<\/jats:title><jats:p>Of 1261 observed patients, 48 displayed spontaneous shrinkage (3.81 per cent). Mean absolute shrinkage was 6.25\u00a0mm, equivalent to 52.1 per cent. Absolute shrinkage correlated with tumour size and follow-up period, whereas relative shrinkage was significantly greater for tumours which were purely intrameatal at diagnosis. There was no correlation between age and the degree of shrinkage.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113001266_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Four per cent of sporadic vestibular schwannomas shrink spontaneously. These findings substantiate the \u2018wait and scan\u2019 strategy for tumours with a largest extrameatal diameter of up to 20\u00a0mm.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113001266","type":"journal-article","created":{"date-parts":[[2013,7,18]],"date-time":"2013-07-18T14:28:45Z","timestamp":1374157725000},"page":"739-743","source":"Crossref","is-referenced-by-count":32,"title":["Spontaneous tumour shrinkage in 1261 observed patients with sporadic vestibular schwannoma"],"prefix":"10.1017","volume":"127","author":[{"given":"X","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Caye-Thomasen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S-E","family":"Stangerup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2013,7,18]]},"reference":[{"key":"S0022215113001266_ref13","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510038013"},{"key":"S0022215113001266_ref11","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000226302.59198.87"},{"key":"S0022215113001266_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(00)80050-2"},{"key":"S0022215113001266_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1808-8694(15)31189-7"},{"key":"S0022215113001266_ref18","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.2003.00670.x"},{"key":"S0022215113001266_ref12","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-199105000-00002"},{"key":"S0022215113001266_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200109000-00021"},{"key":"S0022215113001266_ref3","doi-asserted-by":"publisher","DOI":"10.1258\/0022215041917989"},{"key":"S0022215113001266_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-4486.2008.01705.x"},{"key":"S0022215113001266_ref20","first-page":"722","article-title":"Conservative management of unilateral acoustic neuromas","volume":"21","author":"Tschudi","year":"2000","journal-title":"Am J Otol"},{"key":"S0022215113001266_ref4","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/00129492-200606000-00018","article-title":"The natural history of vestibular schwannoma","volume":"27","author":"Stangerup","year":"2006","journal-title":"Otol Neurotol"},{"key":"S0022215113001266_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200307000-00019"},{"key":"S0022215113001266_ref10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-2006-934112","article-title":"Conservative management of acoustic neuroma","volume":"16","author":"Al","year":"2006","journal-title":"Skull Base"},{"key":"S0022215113001266_ref5","doi-asserted-by":"publisher","DOI":"10.1177\/019459988809800118"},{"key":"S0022215113001266_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/000348949310200705"},{"key":"S0022215113001266_ref1","first-page":"427","article-title":"The origin of acoustic neuromas","volume":"103","author":"Sterkers","year":"1987","journal-title":"Acta Otolaryngol"},{"key":"S0022215113001266_ref19","first-page":"857","article-title":"Effectiveness of conservative management of acoustic neuromas","volume":"21","author":"Shin","year":"2000","journal-title":"Am J Otol"},{"key":"S0022215113001266_ref8","doi-asserted-by":"publisher","DOI":"10.2176\/nmc.46.601"},{"key":"S0022215113001266_ref14","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31816a8955"},{"key":"S0022215113001266_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000180484.24242.54"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113001266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T17:56:35Z","timestamp":1646157395000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113001266\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,18]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2013,8]]}},"alternative-id":["S0022215113001266"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113001266","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,18]]}}}