{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:09:54Z","timestamp":1693994994130},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T00:00:00Z","timestamp":1381968000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113002363_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To report and discuss the outcome of a treatment algorithm for patients with tumour stage 1 glottic squamous cell carcinoma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113002363_sec2\"><jats:title>Method:<\/jats:title><jats:p>A retrospective outcome analysis study was performed using data from a tertiary referral centre.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113002363_sec3\"><jats:title>Results:<\/jats:title><jats:p>Sixty-nine patients were treated with radiotherapy and 26 with surgery, in accordance with the treatment algorithm. Five-year overall survival rates were the same for both treatment groups (92 per cent). Five-year disease-specific survival rates were 100 per cent for surgery, 98 per cent for radiotherapy and 99 per cent overall. The overall 5-year laryngeal preservation rate was 89.1 per cent, being 95.7 per cent for surgery patients and 86.7 per cent for radiotherapy patients (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.502). There was no significant association between laryngeal preservation rates and age (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.779), anterior commissure involvement (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.081), tumour stage (1a or 1b) (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.266) or treatment modality (surgery or radiotherapy; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.220). There was no significant difference in local recurrence rates between the two treatment groups (19.3 per cent for radiotherapy <jats:italic>vs<\/jats:italic> 10.0 per cent for surgery; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.220). The overall 5-year regional recurrence rate was 1.2 per cent.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113002363_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Tumour stage 1 glottic carcinoma can be managed with different treatment modalities, following an individualised treatment algorithm, with results comparable to published outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113002363","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T09:12:01Z","timestamp":1382001121000},"page":"1127-1133","source":"Crossref","is-referenced-by-count":3,"title":["An individualised treatment algorithm for tumour stage 1 glottic squamous cell carcinoma"],"prefix":"10.1017","volume":"127","author":[{"given":"U","family":"Aydil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Akmansu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kizil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6","family":"Yazici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"\u00dcst\u00fcn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Karalo\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"K\u00f6yba\u015fio\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2013,10,17]]},"reference":[{"key":"S0022215113002363_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(03)00059-8"},{"key":"S0022215113002363_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20852"},{"key":"S0022215113002363_ref15","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20993"},{"key":"S0022215113002363_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.9.882"},{"key":"S0022215113002363_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11575"},{"key":"S0022215113002363_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.134.9.965"},{"key":"S0022215113002363_ref17","doi-asserted-by":"publisher","DOI":"10.1102\/1470-7330.2007.0010"},{"key":"S0022215113002363_ref1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199912)21:8<707::AID-HED5>3.3.CO;2-U"},{"key":"S0022215113002363_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20415"},{"key":"S0022215113002363_ref20","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.132.1.59"},{"key":"S0022215113002363_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.018"},{"key":"S0022215113002363_ref8","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0697-5"},{"key":"S0022215113002363_ref9","first-page":"57","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010"},{"key":"S0022215113002363_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199605\/06)18:3<229::AID-HED4>3.0.CO;2-1"},{"key":"S0022215113002363_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200408000-00031"},{"key":"S0022215113002363_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e3181781791"},{"key":"S0022215113002363_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20537"},{"key":"S0022215113002363_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-007-0307-z"},{"key":"S0022215113002363_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20500"},{"key":"S0022215113002363_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21027"},{"key":"S0022215113002363_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20997"},{"key":"S0022215113002363_ref16","first-page":"3","volume-title":"AJCC Cancer Staging Manual","author":"Edge","year":"2010"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113002363","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T19:25:58Z","timestamp":1556047558000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113002363\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,17]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["S0022215113002363"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113002363","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,17]]}}}