{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:56:51Z","timestamp":1768442211391,"version":"3.49.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T00:00:00Z","timestamp":1389830400000},"content-version":"unspecified","delay-in-days":15,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113003277_sec1\"><jats:title>Objective:<\/jats:title><jats:p>The thyroid gland is removed en bloc during laryngectomy. There are no objective criteria for deciding the extent of thyroid gland resection in primary hypopharyngeal cancer cases. The present study aimed to determine the incidence of thyroid gland involvement in hypopharyngeal cancer and identify the various predictors of this involvement.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113003277_sec2\"><jats:title>Method:<\/jats:title><jats:p>This paper reports a retrospective analysis of 358 patients with hypopharyngeal cancer, who underwent total laryngectomy with partial or total pharyngectomy at Tata Memorial Hospital, Mumbai between 2004 and 2010.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113003277_sec3\"><jats:title>Results:<\/jats:title><jats:p>The mean age of this population was 61 years. The pyriform sinus was the most common hypopharyngeal subsite involved (in 89 per cent of cases). Most patients underwent hemi-thyroidectomy as part of their surgery. The thyroid gland was involved in only 13 per cent of cases.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113003277_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Thyroid gland involvement is not common in hypopharyngeal cancer. Cases that involved the post-cricoid area, subglottic extension, extralaryngeal spread or prior tracheostomy were associated with a higher risk of thyroid gland involvement. Ipsilateral thyroidectomy is sufficient in most patients undergoing surgery (laryngectomy with partial or total pharyngectomy) for hypopharyngeal cancers.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113003277","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T06:30:05Z","timestamp":1389853805000},"page":"64-67","source":"Crossref","is-referenced-by-count":14,"title":["Thyroid gland involvement in carcinoma of the hypopharynx"],"prefix":"10.1017","volume":"128","author":[{"given":"P","family":"Joshi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Chaturvedi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Nair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Shivakumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A K","family":"D'Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,1,16]]},"reference":[{"key":"S0022215113003277_ref3","first-page":"729","volume-title":"Cancer: Principles and Practice of Oncology","author":"Mendenhall","year":"2011"},{"key":"S0022215113003277_ref12","first-page":"489","article-title":"Thyroid gland and carcinoma of the hypopharyngeal-laryngeal region [in Italian]","volume":"12","author":"Croce","year":"1991","journal-title":"G Chir"},{"key":"S0022215113003277_ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780080056012"},{"key":"S0022215113003277_ref15","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100098480"},{"key":"S0022215113003277_ref4","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-195510000-00001"},{"key":"S0022215113003277_ref10","volume-title":"Head and Neck Surgery-Otolaryngology","author":"Baily","year":"2001"},{"key":"S0022215113003277_ref11","volume-title":"Otolaryngology: Head and Neck Surgery","author":"Ballenger","year":"1996"},{"key":"S0022215113003277_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(99)00070-6"},{"key":"S0022215113003277_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2008.10.031"},{"key":"S0022215113003277_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1973.00780010311001"},{"key":"S0022215113003277_ref16","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199109000-00003"},{"key":"S0022215113003277_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2007.07.003"},{"key":"S0022215113003277_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21972"},{"key":"S0022215113003277_ref2","first-page":"173","article-title":"Pathologic and clinical considerations in the evaluation of major head and neck specimens resected for cancer","volume":"21","author":"Barnes","year":"1986","journal-title":"Pathol Annu"},{"key":"S0022215113003277_ref6","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197606000-00009"},{"key":"S0022215113003277_ref8","first-page":"9","article-title":"Thyroid gland invasion in advanced laryngeal and hypopharyngeal carcinoma","volume":"13","author":"Ceylan","year":"2004","journal-title":"Kulak Burun Bogaz Ihtis Derg"},{"key":"S0022215113003277_ref9","volume-title":"The Larynx: A Multidisciplinary Approach","author":"Fried","year":"1988"},{"key":"S0022215113003277_ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2273.1997.00835.x"},{"key":"S0022215113003277_ref14","first-page":"564","article-title":"Routine thyroidectomy in total laryngectomy: is it really indicated?","volume":"38","author":"Al-Khatib","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113003277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T21:36:38Z","timestamp":1555968998000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113003277\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0022215113003277"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113003277","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}