{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T12:26:57Z","timestamp":1763036817701},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215113003459_sec1\"><jats:title>Objective:<\/jats:title><jats:p>We aimed to examine the clinical usefulness of a new World Health Organization classification scheme for salivary gland mucoepidermoid carcinoma, and to identify the factors most strongly associated with prognosis and outcome.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113003459_sec2\"><jats:title>Methods:<\/jats:title><jats:p>The clinicopathological features of 45 patients who received treatment for mucoepidermoid carcinoma between 1986 and 2010 were retrospectively investigated.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113003459_sec3\"><jats:title>Results:<\/jats:title><jats:p>The overall disease-specific 5-year survival rate was 81.8 per cent. The rate for patients with low-grade tumours (92.5 per cent) was significantly higher than that for patients with intermediate or high-grade tumours (52.2 per cent). Univariate analysis revealed that five factors were significantly associated with five-year survival: age, tumour stage classification, lymph node status, histological grade and treatment method. Four factors were significant in multivariate analysis: age, sex, tumour stage classification and lymph node status.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215113003459_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>The new World Health Organization classification was useful in predicting disease progression in patients with mucoepidermoid carcinoma. Patients with high-grade tumours or other prognostic factors positively associated with disease progression should be carefully evaluated and monitored.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215113003459","type":"journal-article","created":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T09:59:22Z","timestamp":1390384762000},"page":"91-95","source":"Crossref","is-referenced-by-count":17,"title":["Clinicopathological features of mucoepidermoid carcinoma"],"prefix":"10.1017","volume":"128","author":[{"given":"K","family":"Yamazaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Shodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Matsuyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"S0022215113003459_ref19","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.3025"},{"key":"S0022215113003459_ref6","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26697"},{"key":"S0022215113003459_ref2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920415)69:8<2021::AID-CNCR2820690803>3.0.CO;2-7"},{"key":"S0022215113003459_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(78)90262-3"},{"key":"S0022215113003459_ref11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980625)84:3<153::AID-CNCR6>3.0.CO;2-P"},{"key":"S0022215113003459_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(98)00053-0"},{"key":"S0022215113003459_ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.7.849"},{"key":"S0022215113003459_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2006.12.026"},{"key":"S0022215113003459_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyn045"},{"key":"S0022215113003459_ref4","first-page":"219","volume-title":"Classification of Tumours: Pathology and Genetics of Head and Neck Tumours","author":"Goode","year":"2005"},{"key":"S0022215113003459_ref15","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810701112"},{"key":"S0022215113003459_ref13","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510003174"},{"key":"S0022215113003459_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2006.03.001"},{"key":"S0022215113003459_ref5","volume-title":"Histological Typing of Salivary Gland Tumours","author":"Seifelt","year":"1992"},{"key":"S0022215113003459_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990501)85:9<2057::AID-CNCR24>3.0.CO;2-F"},{"key":"S0022215113003459_ref1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/81.6.696"},{"key":"S0022215113003459_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(20000301)22:3<139::AID-DC2>3.0.CO;2-A"},{"key":"S0022215113003459_ref14","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22647"},{"key":"S0022215113003459_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21083"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215113003459","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T21:36:52Z","timestamp":1555969012000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215113003459\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,1]]}},"alternative-id":["S0022215113003459"],"URL":"https:\/\/doi.org\/10.1017\/s0022215113003459","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1]]}}}