{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:43:35Z","timestamp":1773128615683,"version":"3.50.1"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T00:00:00Z","timestamp":1392854400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114000279_sec1\"><jats:title>Background:<\/jats:title><jats:p>Low-dose clarithromycin has been recommended for the treatment of chronic rhinosinusitis without nasal polyps. However, it is uncertain whether a high dose of clarithromycin is more effective than a low dose.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114000279_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Forty-three chronic rhinosinusitis patients were randomised to low-dose or high-dose clarithromycin groups, and clinical efficacy was evaluated. Pre- and post-treatment measures included: nasal symptom assessment, endoscopic inspection (Lund\u2013Kennedy system), a quality of life questionnaire (the Sino-Nasal Outcome Test 20) and examination of cytokine levels (interleukin-5 and -8) in nasal secretions.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114000279_sec3\"><jats:title>Results:<\/jats:title><jats:p>The high dose of clarithromycin was significantly better in terms of clinical efficacy than the low dose for the treatment of chronic rhinosinusitis (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.025). Significant differences in nasal cytokine levels (interleukin-5 and -8) were also observed between the low-dose and high-dose groups after short-term clarithromycin treatment (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.025).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114000279_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Short-term, high-dose clarithromycin appears to be more effective for the treatment of chronic rhinosinusitis than low-dose clarithromycin.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114000279","type":"journal-article","created":{"date-parts":[[2014,2,20]],"date-time":"2014-02-20T08:52:29Z","timestamp":1392886349000},"page":"236-241","source":"Crossref","is-referenced-by-count":16,"title":["High and low doses of clarithromycin treatment are associated with different clinical efficacies and immunomodulatory properties in chronic rhinosinusitis"],"prefix":"10.1017","volume":"128","author":[{"given":"Y","family":"Fan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,2,20]]},"reference":[{"key":"S0022215114000279_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4193\/Rhino50E2","article-title":"EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. 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