{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:53:58Z","timestamp":1777942438424,"version":"3.51.4"},"reference-count":34,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T00:00:00Z","timestamp":1397520000000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114000747_sec1\"><jats:title>Objective:<\/jats:title><jats:p>This study compared the incidence of salivary fistula between groups with an early or late reintroduction of oral feeding, and identified the predictive factors for salivary fistula.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114000747_sec2\"><jats:title>Methods:<\/jats:title><jats:p>A randomised trial was performed using 89 patients with larynx or hypopharynx cancer, assigned to 2 groups (early or late). In the early group, oral feeding was started 24 hours after total laryngectomy or total pharyngolaryngectomy, and in the late group, it was started from post-operative day 7 onwards. The occurrence of salivary fistula was evaluated in relation to the following variables: early or late oral feeding, nutritional status, cancer stage, surgery performed, and type of neck dissection.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114000747_sec3\"><jats:title>Results:<\/jats:title><jats:p>The incidence of salivary fistula was 27.3 per cent (<jats:italic>n<\/jats:italic>\u00a0=\u00a012) in the early group and 13.3 per cent (<jats:italic>n<\/jats:italic>\u00a0=\u00a06) in the late group (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.10). The following variables were not statistically significant: nutritional status (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.45); tumour location (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.37); type of surgery (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.91) and type of neck dissection (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.62). A significant difference (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.02) between the free margins and invasive carcinoma was observed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114000747_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>The early reintroduction of oral feeding in total laryngectomised patients did not increase the incidence of salivary fistula.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114000747","type":"journal-article","created":{"date-parts":[[2014,4,15]],"date-time":"2014-04-15T13:13:19Z","timestamp":1397567599000},"page":"372-378","source":"Crossref","is-referenced-by-count":8,"title":["Does early oral feeding increase the likelihood of salivary fistula after total laryngectomy?"],"prefix":"10.1017","volume":"128","author":[{"given":"A A","family":"Sousa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J 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