{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:58:39Z","timestamp":1788965919522,"version":"build-2803163510"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,5,23]],"date-time":"2014-05-23T00:00:00Z","timestamp":1400803200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114001078_sec1\"><jats:title>Objective:<\/jats:title><jats:p>Recurrent aphthous stomatitis is a common disease of the oral mucosa, affecting 20 per cent of the general population.<jats:sup>1<\/jats:sup>However, the aetiology of this disease is unknown. This is the first controlled study to compare zinc levels in recurrent aphthous stomatitis patients with those of a well-matched, healthy, control population.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114001078_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Twenty-five patients with a history of recurrent aphthous stomatitis and 25 healthy people (control group) took part in the study. Patients aged between 20 and 40 years with recurrent oral aphthous ulcers less than 1\u00a0cm in diameter were included. Exclusion criteria were pregnancy and lactation, systemic disease (ulcerative colitis, Crohn's disease, Beh\u00e7et's disease), any current medication (topical or systemic), dental surgery during the previous month and deficiencies in iron, folic acid or vitamin B1, B2, B6 or B12. Serum zinc levels were compared between patient and control groups.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114001078_sec3\"><jats:title>Results:<\/jats:title><jats:p>Zinc deficiency was detected in 28 per cent of recurrent aphthous stomatitis patients and in 4 per cent of controls. The mean serum zinc level in the patient group was significantly lower than in the control group.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114001078_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>These results suggest an association between zinc deficiency and recurrent aphthous stomatitis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114001078","type":"journal-article","created":{"date-parts":[[2014,5,22]],"date-time":"2014-05-22T10:17:14Z","timestamp":1400753834000},"page":"531-533","source":"Crossref","is-referenced-by-count":23,"title":["Zinc deficiency in patients with recurrent aphthous stomatitis: a pilot study"],"prefix":"10.1017","volume":"128","author":[{"given":"G S","family":"\u00d6zler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,5,23]]},"reference":[{"key":"S0022215114001078_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-263X.2005.00632.x"},{"key":"S0022215114001078_ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2006.00939.x"},{"key":"S0022215114001078_ref2","first-page":"157","article-title":"Recurrent aphthous stomatitis: etiology, diagnosis, and treatment","volume":"50","author":"Casiglia","year":"2002","journal-title":"Gen Dent"},{"key":"S0022215114001078_ref4","doi-asserted-by":"publisher","DOI":"10.1007\/s11908-003-0073-z"},{"key":"S0022215114001078_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(82)90459-5"},{"key":"S0022215114001078_ref10","first-page":"26","article-title":"Autoimmunity and recurrent aphthous ulcers","volume":"72","author":"Goldstein","year":"1969","journal-title":"Penn Dent J (Phila)"},{"key":"S0022215114001078_ref13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2340\/0001555558251256","article-title":"Local absorption of zinc from wounds treated with various zinc-compounds","volume":"58","author":"Hallmans","year":"1979","journal-title":"Acta Derm Venereol"},{"key":"S0022215114001078_ref8","first-page":"872","article-title":"Hematologic abnormalities in recurrent oral ulceration","volume":"33","author":"Thongprasom","year":"2002","journal-title":"Southeast Asian J Trop Med Public Health"},{"key":"S0022215114001078_ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1991.tb00952.x"},{"key":"S0022215114001078_ref9","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00369.x"},{"key":"S0022215114001078_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-197705000-00016"},{"key":"S0022215114001078_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90072-0"},{"key":"S0022215114001078_ref5","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1600-0714.2009.00867.x","article-title":"Reduced dietary intake of vitamin B12 and folate in patients with recurrent aphthous stomatitis","volume":"39","author":"Kozlak","year":"2010","journal-title":"J Oral Pathol Med"},{"key":"S0022215114001078_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03482.x"},{"key":"S0022215114001078_ref11","first-page":"515","article-title":"Autoimmunity in oral diseases, with special reference to recurrent oral ulceration","volume":"61","author":"Lehner","year":"1968","journal-title":"Proc R Soc Med"},{"key":"S0022215114001078_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(91)90493-V"},{"key":"S0022215114001078_ref15","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.10.070190.002215"},{"key":"S0022215114001078_ref7","first-page":"381","article-title":"Hematologic status in patients with recurrent aphthous stomatitis in Jordan","volume":"27","author":"Burgan","year":"2006","journal-title":"Saudi Med J"},{"key":"S0022215114001078_ref17","doi-asserted-by":"publisher","DOI":"10.4012\/dmj.22.21"},{"key":"S0022215114001078_ref19","first-page":"734","article-title":"The therapeutic and prophylactic role of oral zinc sulfate in management of recurrent aphthous stomatitis (RAS) in comparison with dapsone","volume":"29","author":"Sharquie","year":"2008","journal-title":"Saudi Med J"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215114001078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,26]],"date-time":"2024-05-26T21:39:08Z","timestamp":1716759548000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215114001078\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,23]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0022215114001078"],"URL":"https:\/\/doi.org\/10.1017\/s0022215114001078","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,23]]}}}