{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:36:06Z","timestamp":1697441766917},"reference-count":11,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114001200_sec1\"><jats:title>Objective:<\/jats:title><jats:p>This paper reports a rare case of a human immunodeficiency virus infected man with gummatous syphilis of the face.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114001200_sec2\"><jats:title>Case report:<\/jats:title><jats:p>A 39-year-old man presented with an ulcer of the face which had been slowly progressive over the previous 6 years. Examination showed an ulcerative lesion of the midface involving the cheeks, and completely destroying the nose, the upper lip and part of the lower lip. The teeth and gums were exposed. The ulcer had a moist, purulent base with rolled edges. The patient had human immunodeficiency virus, with a cluster of differentiation 4 count of 641 cells per \u00b5l. The rapid plasma reagin test titre was 1:1024 and the<jats:italic>Treponema pallidum<\/jats:italic>haemagglutination assay result was positive. Biopsy showed non-necrotising granulomata with a negative Warthin\u2013Starry silver stain. There was a dramatic response to treatment with penicillin.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114001200_sec3\"><jats:title>Conclusion:<\/jats:title><jats:p>This case study is a reminder that syphilis needs to be considered in the differential diagnosis of unusual presentations involving skin and bone.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114001200","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T11:18:00Z","timestamp":1402312680000},"page":"557-560","source":"Crossref","is-referenced-by-count":5,"title":["A rare case of a chronic syphilitic gumma in a man infected with human immunodeficiency virus"],"prefix":"10.1017","volume":"128","author":[{"given":"S D","family":"Masege","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Karstaedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"S0022215114001200_ref11","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000337079.12137.89"},{"key":"S0022215114001200_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/157.3.606"},{"key":"S0022215114001200_ref8","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-107-4-492"},{"key":"S0022215114001200_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3156.2004.01344.x"},{"key":"S0022215114001200_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1964.03860120104011"},{"key":"S0022215114001200_ref3","first-page":"374","article-title":"Gummatous lesions in men infected with human immunodeficiency virus and syphilis","volume":"66","author":"Hay","year":"1990","journal-title":"Genitourin Med"},{"key":"S0022215114001200_ref1","doi-asserted-by":"publisher","DOI":"10.1086\/513427"},{"key":"S0022215114001200_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-198808000-00012"},{"key":"S0022215114001200_ref5","first-page":"70","article-title":"The Oslo study of untreated syphilis review and commentary","volume":"32","author":"Harrison","year":"1956","journal-title":"Br J Vener Dis"},{"key":"S0022215114001200_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01061-8"},{"key":"S0022215114001200_ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2340\/0001555575153154","article-title":"The prozone phenomenon in secondary syphilis","volume":"75","author":"Taniguchi","year":"1995","journal-title":"Acta Derm Venereol"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215114001200","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T03:58:32Z","timestamp":1689307112000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215114001200\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2014,6]]}},"alternative-id":["S0022215114001200"],"URL":"https:\/\/doi.org\/10.1017\/s0022215114001200","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6]]}}}