{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:16:20Z","timestamp":1790820980687,"version":"4.1.0"},"reference-count":22,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T00:00:00Z","timestamp":1411084800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec id=\"S0022215114001972_sec1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine whether the distribution of membrane lesions associated with M\u00e9ni\u00e8re's disease is random, as might be expected from a pervasive process such as hydrops, or orderly, as might be expected if membrane resistance is graded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215114001972_sec2\">\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>A meta-analysis of temporal bone reports on 184 specimens demonstrating endolymphatic hydrops was undertaken to determine membrane lesion evolution and distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215114001972_sec3\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Lesion distribution was found to be orderly and cochleocentric. No random scattershot lesions were reported in any study. Disease always started in the cochlear apex, even in non-symptomatic cases, and then involved the saccule, utricle, ampullae and canal system in that precise sequence as the disease progressed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"S0022215114001972_sec4\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The orderly lesion progression in the otopathology associated with M\u00e9ni\u00e8re's disease suggests that the hydropic process has a graded non-random effect on the labyrinth. These findings suggest a pathological staging system that may be useful in temporal bone evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1017\/s0022215114001972","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T06:45:29Z","timestamp":1411109129000},"page":"859-865","source":"Crossref","is-referenced-by-count":84,"title":["Endolymphatic hydrops and M\u00e9ni\u00e8re's disease: a lesion meta-analysis"],"prefix":"10.1017","volume":"128","author":[{"given":"D J","family":"Pender","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"S0022215114001972_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200501000-00013"},{"key":"S0022215114001972_ref18","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310900321"},{"key":"S0022215114001972_ref2","first-page":"711","article-title":"Some diseases of the inner ear [in French]","volume":"1872","author":"Duplay","journal-title":"Arch Gen Med"},{"key":"S0022215114001972_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.06.004"},{"key":"S0022215114001972_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/000348946207100417"},{"key":"S0022215114001972_ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1982.00790560001001"},{"key":"S0022215114001972_ref13","doi-asserted-by":"publisher","DOI":"10.1177\/00034894800896S201"},{"key":"S0022215114001972_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000390103"},{"key":"S0022215114001972_ref1","first-page":"597","article-title":"Report on lesions of the inner ear causing symptoms of apolectiform cerebral congestion [in French]","volume":"16","author":"M\u00e9ni\u00e8re","year":"1861","journal-title":"Gazzette Medicale de Paris"},{"key":"S0022215114001972_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100003947"},{"key":"S0022215114001972_ref4","first-page":"290","volume":"12","author":"Witmaack","year":"1926","journal-title":"Handbook of Special Pathological Anatomy and Histology"},{"key":"S0022215114001972_ref6","first-page":"58","article-title":"The syndrome of physical or intrinsic allergy of the head","volume":"21","author":"Williams","year":"1946","journal-title":"Proc Staff Meet Mayo Clin"},{"key":"S0022215114001972_ref8","first-page":"1","article-title":"Endolymphatic hydrops. An overview and classification","volume":"106","author":"Schuknecht","year":"1983","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"key":"S0022215114001972_ref17","doi-asserted-by":"publisher","DOI":"10.1080\/00016480902729827"},{"key":"S0022215114001972_ref9","first-page":"1","article-title":"The histopathology of M\u00e9ni\u00e8re's disease","volume":"340","author":"Antoli-Candela","year":"1976","journal-title":"Acta Otolaryngol"},{"key":"S0022215114001972_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/000348946507400402"},{"key":"S0022215114001972_ref14","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199303000-00007"},{"key":"S0022215114001972_ref22","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.129813"},{"key":"S0022215114001972_ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1940.00660020683005"},{"key":"S0022215114001972_ref16","volume-title":"The Prince","author":"Machiavelli","year":"1532"},{"key":"S0022215114001972_ref19","doi-asserted-by":"publisher","DOI":"10.1177\/000348946907800311"},{"key":"S0022215114001972_ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1942.00670010861002"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215114001972","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T19:43:45Z","timestamp":1555875825000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215114001972\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,19]]},"references-count":22,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0022215114001972"],"URL":"https:\/\/doi.org\/10.1017\/s0022215114001972","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,19]]}}}