{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:06:31Z","timestamp":1760043991418},"reference-count":27,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114002552_sec1\"><jats:title>Background:<\/jats:title><jats:p>Eosinophilic angiocentric fibrosis is a rare benign disorder of the upper respiratory tract. It is slow growing and progressive, with characteristic histological appearances.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002552_sec2\"><jats:title>Methods:<\/jats:title><jats:p>We report the largest single-institution case series of sinonasal eosinophilic angiocentric fibrosis to date, comprising nine patients. The current literature is reviewed, showing emerging evidence that this condition may belong to the immunoglobulin G4-related disease spectrum.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002552_sec3\"><jats:title>Results:<\/jats:title><jats:p>The series comprised five female and four male patients, with a mean age at presentation of 53 years. All were treated surgically. Six patients had no signs of recurrent disease after an average of 8.5 years. One patient went on to develop granulomatosis with polyangiitis (Wegener's granulomatosis), which required immunosuppressive therapy.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002552_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>The first-line management of this rare condition is complete surgical excision. Chronic granulomatous conditions, including granulomatosis with polyangiitis, should be excluded before a diagnosis is made, and patients should be carefully followed.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114002552","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T10:21:09Z","timestamp":1416219669000},"page":"1071-1077","source":"Crossref","is-referenced-by-count":16,"title":["Eosinophilic angiocentric fibrosis of the nose and sinuses"],"prefix":"10.1017","volume":"128","author":[{"given":"J","family":"Rimmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Andrews","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V J","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"S0022215114002552_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-008-0077-y"},{"key":"S0022215114002552_ref20","first-page":"E321","article-title":"Immunoglobulin G4-related sclerosing disease of the paranasal sinus","volume":"35","author":"Lindau","year":"2012","journal-title":"Head Neck"},{"key":"S0022215114002552_ref17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/194589240602000117","article-title":"Eosinophilic angiocentric fibrosis of the sinonasal tract in a male patient with chronic bowel inflammation","volume":"20","author":"Slovik","year":"2006","journal-title":"Am J Rhinol"},{"key":"S0022215114002552_ref9","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23396"},{"key":"S0022215114002552_ref15","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200607000-00040"},{"key":"S0022215114002552_ref4","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2012.07.008"},{"key":"S0022215114002552_ref13","doi-asserted-by":"publisher","DOI":"10.1080\/01676830600674544"},{"key":"S0022215114002552_ref1","first-page":"165","volume-title":"Tumours of the Nose, Paranasal Sinuses and Nasopharynx","author":"Lund","year":"2014"},{"key":"S0022215114002552_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(83)80041-6"},{"key":"S0022215114002552_ref5","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318213889e"},{"key":"S0022215114002552_ref6","doi-asserted-by":"publisher","DOI":"10.1258\/0022215053419989"},{"key":"S0022215114002552_ref7","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2010.95"},{"key":"S0022215114002552_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2005.09.035"},{"key":"S0022215114002552_ref10","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10041"},{"key":"S0022215114002552_ref14","doi-asserted-by":"publisher","DOI":"10.1258\/0022215011907037"},{"key":"S0022215114002552_ref26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2340\/00015555746364","article-title":"On the efficacy of dapsone in granuloma faciale","volume":"74","author":"Van de Kerkhof","year":"1994","journal-title":"Acta Derm Venereol"},{"key":"S0022215114002552_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2007.02840.x"},{"key":"S0022215114002552_ref19","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e32834ddb4a"},{"key":"S0022215114002552_ref21","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A2786"},{"key":"S0022215114002552_ref22","first-page":"41","article-title":"Eosinophilic angiocentric fibrosis as a cause of nasal obstruction","volume":"40","author":"Owa","year":"2001","journal-title":"Rhinology"},{"key":"S0022215114002552_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.02.002"},{"key":"S0022215114002552_ref24","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.8.640"},{"key":"S0022215114002552_ref25","doi-asserted-by":"publisher","DOI":"10.1309\/7D97-83KY-6NW2-5608"},{"key":"S0022215114002552_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/art.27435"},{"key":"S0022215114002552_ref11","doi-asserted-by":"publisher","DOI":"10.1177\/000348940511400107"},{"key":"S0022215114002552_ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1985.tb02801.x"},{"key":"S0022215114002552_ref16","first-page":"E155","article-title":"Eosinophilic angiocentric fibrosis","volume":"37","author":"Holsinger","year":"2008","journal-title":"J Otolaryngol Head Neck Surg"}],"container-title":["The Journal of Laryngology &amp; 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