{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T06:08:19Z","timestamp":1764828499195},"reference-count":31,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T00:00:00Z","timestamp":1420416000000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114002680_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To investigate whether thymoquinone has any eliminative effects against inner-ear damage caused by acoustic trauma.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002680_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Thirty-two male rats were divided into four groups. Group 1 was only exposed to acoustic trauma. Group 2 was given thymoquinone 24 hours before acoustic trauma and continued to receive it for 10 days after the trauma. Group 3 was only treated with thymoquinone, for 10 days. Group 4, the control group, suffered no trauma and received saline instead of thymoquinone. Groups 1 and 2 were exposed to acoustic trauma using 105\u00a0dB SPL white noise for 4 hours.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002680_sec3\"><jats:title>Results:<\/jats:title><jats:p>There was a significant decrease in distortion product otoacoustic emission values and an increase in auditory brainstem response thresholds in group 1 on days 1, 5 and 10, compared with baseline measurements. In group 2, a decrease in distortion product otoacoustic emission values and an increase in auditory brainstem response threshold were observed on day 1 after acoustic trauma, but measurements were comparable to baseline values on days 5 and 10. In group 3, thymoquinone had no detrimental effects on hearing. Similarly, the control group showed stable results.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002680_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Thymoquinone was demonstrated to be a reparative rather than preventive treatment that could be used to relieve acoustic trauma.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114002680","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T08:49:26Z","timestamp":1420447766000},"page":"38-45","source":"Crossref","is-referenced-by-count":16,"title":["Thymoquinone treatment for inner-ear acoustic trauma in rats"],"prefix":"10.1017","volume":"129","author":[{"given":"F","family":"Aksoy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Yenigun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Veyseller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Ozturan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Ozturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"S0022215114002680_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2006.12.005"},{"key":"S0022215114002680_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/BF02114761"},{"key":"S0022215114002680_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.02.008"},{"key":"S0022215114002680_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.04.015"},{"key":"S0022215114002680_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(97)00181-0"},{"key":"S0022215114002680_ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000071061"},{"key":"S0022215114002680_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2008.00607.x"},{"key":"S0022215114002680_ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2006.01417.x"},{"key":"S0022215114002680_ref19","first-page":"213","article-title":"Determination of oxygen radical absorbance capacity of black cumin (Nigella sativa) seed quinone compounds","volume":"6","author":"Tesarova","year":"2011","journal-title":"Nat Prod Commun"},{"key":"S0022215114002680_ref2","first-page":"95","volume-title":"Scientific Basis of Noise-induced Hearing Loss","author":"Miller","year":"1996"},{"key":"S0022215114002680_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010043"},{"key":"S0022215114002680_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)02733-5"},{"key":"S0022215114002680_ref27","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(00)00106-4"},{"key":"S0022215114002680_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2005.06.004"},{"key":"S0022215114002680_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2003.11.016"},{"key":"S0022215114002680_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-012-0279-z"},{"key":"S0022215114002680_ref5","first-page":"139","article-title":"Mechanisms and prevention of noise-induced hearing loss [in Japanese]","volume":"16","author":"Miller","year":"2006","journal-title":"Otology Japan"},{"key":"S0022215114002680_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.02.029"},{"key":"S0022215114002680_ref22","first-page":"111","volume-title":"Seminars in Hearing. 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