{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T18:37:08Z","timestamp":1770835028159,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T00:00:00Z","timestamp":1416787200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114002709_sec1\"><jats:title>Objectives:<\/jats:title><jats:p>To assess the clinical utility of elective neck dissection in node-negative recurrent laryngeal carcinoma after curative radiotherapy for initial early glottic cancer.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002709_sec2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective review was undertaken of 110 consecutive early glottic cancer patients who developed laryngeal recurrence after radiotherapy (34 recurrent T<jats:sub>1<\/jats:sub>, 36 recurrent T<jats:sub>2<\/jats:sub>, 29 recurrent T<jats:sub>3<\/jats:sub>and 11 recurrent T<jats:sub>4a<\/jats:sub>) and received salvage laryngeal surgery between 1995 and 2005.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002709_sec3\"><jats:title>Results:<\/jats:title><jats:p>Six patients presented with laryngeal and neck recurrence and underwent salvage laryngectomy with therapeutic neck dissection, 97 patients with recurrent node-negative tumours underwent salvage laryngeal surgery without neck dissection and only 7 underwent elective neck dissection. No occult positive lymph nodes were documented in neck dissection specimens. During follow up, only three patients with neck failure were recorded, all in the group without neck dissection. There was no significant association between the irradiation field (larynx plus neck<jats:italic>vs<\/jats:italic>larynx) and the development of regional failure. A higher rate of post-operative pharyngocutaneous fistula development occurred in the neck dissection group than in the group without neck dissection (57.2 per cent<jats:italic>vs<\/jats:italic>13.4 per cent,<jats:italic>p<\/jats:italic>\u00a0=\u00a00.01). Multivariate logistic regression analysis showed that early (recurrent tumour-positive, node-positive) or delayed (recurrent tumour-positive, node-negative) neck relapse was not significantly related to the stage of the initial tumour or the recurrent tumour. An age of less than 60 years was significantly associated with early neck failure (recurrent tumour-positive, node-positive).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002709_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Owing to the low occult neck disease rate and high post-operative fistula rate, elective neck dissection is not recommended for recurrent node-negative laryngeal tumours after radiation therapy if the initial tumour was an early glottic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114002709","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T06:17:44Z","timestamp":1416809864000},"page":"1089-1094","source":"Crossref","is-referenced-by-count":27,"title":["Is elective neck dissection necessary in cases of laryngeal recurrence after previous radiotherapy for early glottic cancer?"],"prefix":"10.1017","volume":"128","author":[{"given":"A","family":"Deganello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Meccariello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Bini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Paiar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mannelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"S0022215114002709_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20974"},{"key":"S0022215114002709_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20798"},{"key":"S0022215114002709_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980901)83:5<910::AID-CNCR16>3.0.CO;2-Y"},{"key":"S0022215114002709_ref18","volume-title":"American Joint Committee on Cancer Staging Manual","author":"Edge","year":"2009"},{"key":"S0022215114002709_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20907"},{"key":"S0022215114002709_ref16","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e31815f6f25"},{"key":"S0022215114002709_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.01.084"},{"key":"S0022215114002709_ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-003-0727-3"},{"key":"S0022215114002709_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2005.05.002"},{"key":"S0022215114002709_ref5","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25305"},{"key":"S0022215114002709_ref4","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21739"},{"key":"S0022215114002709_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.03.022"},{"key":"S0022215114002709_ref1","first-page":"603","article-title":"Treatment of early-stage glottic cancer: meta-analysis comparison of laser excision versus radiotherapy","volume":"38","author":"Higgins","year":"2009","journal-title":"J Otolaryngol Head Neck Surg"},{"key":"S0022215114002709_ref12","first-page":"335","article-title":"Evolution of elective neck dissection in N0 laryngeal cancer","volume":"26","author":"Gallo","year":"2006","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"S0022215114002709_ref21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/lary.20675","article-title":"Management of the N0 neck in recurrent laryngeal squamous cell carcinoma","volume":"120","author":"Bohannon","year":"2010","journal-title":"Laryngoscope"},{"key":"S0022215114002709_ref11","first-page":"216","article-title":"Effectiveness and pitfalls of elective neck dissection in N0 laryngeal cancer","volume":"31","author":"Deganello","year":"2011","journal-title":"Acta Otorhinolaryngol Ital"},{"key":"S0022215114002709_ref22","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00002"},{"key":"S0022215114002709_ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2008.03.013"},{"key":"S0022215114002709_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2009.12.037"},{"key":"S0022215114002709_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2005.05.018"},{"key":"S0022215114002709_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20837"},{"key":"S0022215114002709_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000199591.92336.06"},{"key":"S0022215114002709_ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1996.01890190038010"},{"key":"S0022215114002709_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80341-1"}],"container-title":["The Journal of Laryngology &amp; 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