{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:09:02Z","timestamp":1773936542796,"version":"3.50.1"},"reference-count":24,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T00:00:00Z","timestamp":1416182400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2014,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114002710_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To determine the efficacy of intratympanic methylprednisolone injections for treating sudden sensorineural hearing loss.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002710_sec2\"><jats:title>Method:<\/jats:title><jats:p>A retrospective chart review was performed to identify patients suffering from sudden sensorineural hearing loss with no recovery after oral steroids. Patients were given up to three intratympanic methylprednisolone injections at one-week intervals. They were classified according to their functional hearing class, remission was monitored and potential factors affecting prognosis were analysed.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002710_sec3\"><jats:title>Results:<\/jats:title><jats:p>Intratympanic injections provide effective salvage therapy for sudden sensorineural hearing loss (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.039). Changes in pure tone average and speech discrimination score were analysed following intratympanic methylprednisolone injections. The pure tone average reached a plateau after the second injection; however, the speech discrimination score improved until after the third injection. Hearing improvement after intratympanic injections mainly occurred at low frequencies. The interval between symptoms appearing and intratympanic injections starting was not significantly associated with remission (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.680).<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002710_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>A delay between symptom onset and the first intratympanic methylprednisolone injection does not seem to affect prognosis.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114002710","type":"journal-article","created":{"date-parts":[[2014,11,17]],"date-time":"2014-11-17T06:05:54Z","timestamp":1416204354000},"page":"1044-1049","source":"Crossref","is-referenced-by-count":18,"title":["Intratympanic steroid injection as a salvage treatment for sudden sensorineural hearing loss"],"prefix":"10.1017","volume":"128","author":[{"given":"S","family":"Belhassen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"S0022215114002710_ref21","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197603000-00008"},{"key":"S0022215114002710_ref20","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181f7aba3"},{"key":"S0022215114002710_ref18","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215110002124"},{"key":"S0022215114002710_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.03.081"},{"key":"S0022215114002710_ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000320838"},{"key":"S0022215114002710_ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199907001-00001"},{"key":"S0022215114002710_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.015"},{"key":"S0022215114002710_ref6","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198405000-00014"},{"key":"S0022215114002710_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2007.01.022"},{"key":"S0022215114002710_ref5","doi-asserted-by":"publisher","DOI":"10.1080\/003655402_000028037"},{"key":"S0022215114002710_ref23","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.679"},{"key":"S0022215114002710_ref4","doi-asserted-by":"publisher","DOI":"10.1177\/000348947708600406"},{"key":"S0022215114002710_ref14","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/MAO.0b013e31802fba7a","article-title":"Intratympanic methylprednisolone for sudden sensorineural hearing loss","volume":"28","author":"Kili\u00e7","year":"2007","journal-title":"Otol Neurotol"},{"key":"S0022215114002710_ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200101000-00005"},{"key":"S0022215114002710_ref24","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e31824b78da"},{"key":"S0022215114002710_ref13","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181c34f18"},{"key":"S0022215114002710_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2004.04.004"},{"key":"S0022215114002710_ref8","doi-asserted-by":"publisher","DOI":"10.3109\/00016481003793766"},{"key":"S0022215114002710_ref17","first-page":"186","article-title":"American Academy of Otolaryngology \u2013 Head and Neck Surgery Foundation","volume":"113","year":"1995","journal-title":"Otolaryngol Head Neck Surg"},{"key":"S0022215114002710_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-006-0065-3"},{"key":"S0022215114002710_ref22","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1261257"},{"key":"S0022215114002710_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1980.00790360050013"},{"key":"S0022215114002710_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mao.0000185052.07513.5a"},{"key":"S0022215114002710_ref19","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2010.3.3.122"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215114002710","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,21]],"date-time":"2019-04-21T17:23:54Z","timestamp":1555867434000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215114002710\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,17]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0022215114002710"],"URL":"https:\/\/doi.org\/10.1017\/s0022215114002710","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,17]]}}}