{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:49:33Z","timestamp":1760888973474},"reference-count":15,"publisher":"Cambridge University Press (CUP)","issue":"S1","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"unspecified","delay-in-days":36,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114002989_sec1\"><jats:title>Background:<\/jats:title><jats:p>Panendoscopy is routinely used for the identification of occult second primary tumours in head and neck squamous cell carcinoma. However, its role in low risk subgroups, particularly non-smoking, non-drinking patients and patients presenting with early stage oral cavity lesions, is debatable.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002989_sec2\"><jats:title>Methods:<\/jats:title><jats:p>The records of 112 patients with T<jats:sub>1<\/jats:sub> or T<jats:sub>2<\/jats:sub> oral tongue squamous cell carcinoma were retrospectively reviewed. Demographic, disease characteristics and survival data were collected.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002989_sec3\"><jats:title>Results:<\/jats:title><jats:p>Average follow-up duration was 71.7 months (range, 3.6\u2013238.3 months). Thirty-five patients died within this period. Thirteen second primary events were identified in 11 patients, with all but 2 tumours in the oral cavity or oropharynx. There was a single synchronous primary \u2013 a lung adenocarcinoma; all other events were metachronous. No non-smoking, non-drinking patients re-presented with a second primary tumour; tobacco and alcohol use are clearly risk factors for development of a second primary tumour.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002989_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>The role of panendoscopy for identifying synchronous primary tumours in patients with early stage oral tongue squamous cell carcinoma should be re-evaluated, particularly in non-smoking, non-drinking patients who are at low risk of second primary development. Close follow up with regular clinical examination including flexible fibre-optic endoscopy may be sufficient in this subgroup.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114002989","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T09:20:59Z","timestamp":1423214459000},"page":"S27-S31","source":"Crossref","is-referenced-by-count":17,"title":["A role for panendoscopy? Second primary tumour in early stage squamous cell carcinoma of the oral tongue"],"prefix":"10.1017","volume":"129","author":[{"given":"K","family":"Koo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Wiesenfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T A","family":"Iseli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"S0022215114002989_ref15","article-title":"Risk of perforation using rigid oesophagoscopy in the distal part of oesophagus","volume":"59","author":"Wennervaldt","year":"2012","journal-title":"Dan Med J"},{"key":"S0022215114002989_ref14","first-page":"1358","article-title":"Multiple primary malignant tumours. 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