{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T07:00:52Z","timestamp":1768806052780,"version":"3.49.0"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T00:00:00Z","timestamp":1418601600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114002990_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To explore the significance of the tumour necrosis factor-\u03b1\/interleukin-10 ratio and the effect of continuous positive airway pressure in patients with different degrees of obstructive sleep apnoea hypopnoea syndrome severity.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002990_sec2\"><jats:title>Method:<\/jats:title><jats:p>This study comprised 135 patients with obstructive sleep apnoea hypopnoea syndrome and 94 control subjects.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002990_sec3\"><jats:title>Results:<\/jats:title><jats:p>Tumour necrosis factor-\u03b1 and tumour necrosis factor-\u03b1\/interleukin-10 ratio values were significantly higher in the obstructive sleep apnoea hypopnoea syndrome group than in the control group, but interleukin-10 was significantly lower. Tumour necrosis factor-\u03b1\/interleukin-10 ratio values increased in line with the severity of obstructive sleep apnoea hypopnoea syndrome. In multivariate analysis, the tumour necrosis factor-\u03b1\/interleukin-10 ratio correlated positively with the apnoea\u2013hypopnoea index and all indices of obstructive sleep apnoea hypopnoea syndrome, except for age, body mass index and neck circumference. After one month of continuous positive airway pressure therapy, levels of tumour necrosis factor-\u03b1 decreased; interleukin-10 showed no change.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114002990_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>The results suggest that inflammation is activated and anti-inflammatory cytokines are decreased in obstructive sleep apnoea hypopnoea syndrome patients. Tumour necrosis factor-\u03b1\/interleukin-10 ratio may prove useful for severity monitoring and management of obstructive sleep apnoea hypopnoea syndrome patients, and may reduce the need for polysomnography.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114002990","type":"journal-article","created":{"date-parts":[[2014,12,15]],"date-time":"2014-12-15T10:49:13Z","timestamp":1418640553000},"page":"73-78","source":"Crossref","is-referenced-by-count":17,"title":["Tumour necrosis factor-\u03b1\/interleukin-10 ratio in patients with obstructive sleep apnoea hypopnoea syndrome"],"prefix":"10.1017","volume":"129","author":[{"given":"H","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2014,12,15]]},"reference":[{"key":"S0022215114002990_ref8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1189\/jlb.0904484","article-title":"New insights into the molecular mechanism of interleukin-10-mediated immunosuppression","volume":"77","author":"Gr\u00fctz","year":"2005","journal-title":"J Leukoc Biol"},{"key":"S0022215114002990_ref13","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-031929"},{"key":"S0022215114002990_ref18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5664\/jcsm.27497","article-title":"Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults","volume":"5","author":"Epstein","year":"2009","journal-title":"J Clin Sleep Med"},{"key":"S0022215114002990_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2013.07.006"},{"key":"S0022215114002990_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-305X(02)00135-0"},{"key":"S0022215114002990_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.07.003"},{"key":"S0022215114002990_ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199712)173:3<335::AID-JCP5>3.0.CO;2-O"},{"key":"S0022215114002990_ref20","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.67"},{"key":"S0022215114002990_ref4","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052627.99976.18"},{"key":"S0022215114002990_ref10","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/675320"},{"key":"S0022215114002990_ref3","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.7.508"},{"key":"S0022215114002990_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0555-4"},{"key":"S0022215114002990_ref9","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/245476"},{"key":"S0022215114002990_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-011-0492-2"},{"key":"S0022215114002990_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/33.6.739"},{"key":"S0022215114002990_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12073"},{"key":"S0022215114002990_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-012-0726-y"},{"key":"S0022215114002990_ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.84.8.5894"},{"key":"S0022215114002990_ref6","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.48.2366"},{"key":"S0022215114002990_ref1","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2012.658864"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215114002990","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T22:56:17Z","timestamp":1598568977000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215114002990\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,15]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1]]}},"alternative-id":["S0022215114002990"],"URL":"https:\/\/doi.org\/10.1017\/s0022215114002990","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,15]]}}}