{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:21:38Z","timestamp":1761744098213},"reference-count":18,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215114003442_sec1\"><jats:title>Background:<\/jats:title><jats:p>Nasal polyposis is one of the most common inflammatory pathologies of the nasal cavity. Eosinophilic inflammation plays an important role in the pathogenesis. This study aimed to investigate soluble tumour necrosis factor related apoptosis-inducing ligand levels and eosinophil count in nasal polyposis patients.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114003442_sec2\"><jats:title>Methods:<\/jats:title><jats:p>The study was performed on 24 adult nasal polyposis patients and 24 age-matched healthy individuals. The patients had not received any medical or surgical treatment. Pre-operative computed tomography scans were assessed using the Lund\u2013MacKay grading system, and soluble tumour necrosis factor related apoptosis-inducing ligand levels were measured with a sandwich enzyme-linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114003442_sec3\"><jats:title>Results:<\/jats:title><jats:p>Compared with controls, eosinophil levels in nasal polyposis patients were increased (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.024), but there was no significant difference in soluble tumour necrosis factor related apoptosis-inducing ligand levels (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.529). The Lund\u2013Mackay mean grading was 12.43\u00a0\u00b1\u00a06.9. There was no correlation between soluble tumour necrosis factor related apoptosis-inducing ligand level and Lund\u2013Mackay grading and eosinophil count.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215114003442_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>There was no relationship between soluble tumour necrosis factor related apoptosis-inducing ligand level and blood eosinophil or clinical markers; however, soluble tumour necrosis factor related apoptosis-inducing ligand level remains of interest for future studies.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215114003442","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T02:40:03Z","timestamp":1423190403000},"page":"250-253","source":"Crossref","is-referenced-by-count":2,"title":["Serum soluble tumour necrosis factor related apoptosis-inducing ligand level and peripheral eosinophil count in patients with nasal polyposis"],"prefix":"10.1017","volume":"129","author":[{"given":"A","family":"Bisgin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Eyigor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Osma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M D","family":"Yilmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A D","family":"Yalcin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"S0022215114003442_ref1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S2379"},{"key":"S0022215114003442_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.01.482"},{"key":"S0022215114003442_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.aller.2010.05.001"},{"key":"S0022215114003442_ref17","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.133.7.701"},{"key":"S0022215114003442_ref14","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0631"},{"key":"S0022215114003442_ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1996.tb08306.x"},{"key":"S0022215114003442_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-11-192"},{"key":"S0022215114003442_ref11","first-page":"PI11","article-title":"Serum soluble TRAIL levels in patients with severe persistent allergic asthma: its relation to omalizumab treatment","volume":"18","author":"Yalcin","year":"2012","journal-title":"Med Sci Monit"},{"key":"S0022215114003442_ref12","first-page":"LE9","article-title":"The relation of sTRAIL levels and quality of life in severe persistent allergic asthma patients using omalizumab","volume":"18","author":"Yalcin","year":"2012","journal-title":"Med Sci Monit"},{"key":"S0022215114003442_ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-58"},{"key":"S0022215114003442_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2009.03058.x"},{"key":"S0022215114003442_ref2","first-page":"87","article-title":"Pathogenesis of nasal polyps","volume":"15","author":"Tos","year":"1977","journal-title":"Rhinology"},{"key":"S0022215114003442_ref9","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2011-300339"},{"key":"S0022215114003442_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq042"},{"key":"S0022215114003442_ref7","doi-asserted-by":"publisher","DOI":"10.1177\/000348940010900306"},{"key":"S0022215114003442_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2005.08.010"},{"key":"S0022215114003442_ref3","first-page":"17","volume-title":"Nasal Polyps: Epidemiology, Pathogenesis and Treatment","author":"Drake-Lee","year":"1997"},{"key":"S0022215114003442_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2012.02.028"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215114003442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,20]],"date-time":"2019-04-20T23:45:48Z","timestamp":1555803948000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215114003442\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0022215114003442"],"URL":"https:\/\/doi.org\/10.1017\/s0022215114003442","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}