{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:28:52Z","timestamp":1761823732178},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S002221511500016X_sec1\"><jats:title>Objective:<\/jats:title><jats:p>To review the phenomenon and implications of temporal bone and craniofacial bone staining in the context of prolonged exposure to tetracycline antibiotic.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511500016X_sec2\"><jats:title>Methods:<\/jats:title><jats:p>Case report and literature review.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511500016X_sec3\"><jats:title>Results:<\/jats:title><jats:p>A 52-year-old male with a 5-year history of tetracycline use presented to undergo tympanomastoidectomy and was found to have an unusual rusty green pigmentation of the entire aspect of the exposed temporal bone. A literature review revealed more than 20 cases of tetracycline-induced pigmentation of intraoral maxillary and mandibular bone, and 2 prior cases involving the cranial bones.<\/jats:p><\/jats:sec><jats:sec id=\"S002221511500016X_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Tissue and organ pigmentation is an unexpected and unfavourable consequence of the use of tetracyclines, particularly minocycline. Tetracycline is contraindicated in children because of the risk for dysosteogenesis and enamel hypoplasia. In adults, although the unusual staining may present as an unexpected dilemma upon surgical exposure, current research shows no significant clinical consequences for this type of pigmentation.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s002221511500016x","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T10:41:13Z","timestamp":1423737673000},"page":"276-278","source":"Crossref","is-referenced-by-count":12,"title":["Rusty green stained temporal bone associated with exposure to tetracycline: an unusual presentation of black bone disease"],"prefix":"10.1017","volume":"129","author":[{"given":"B","family":"Farahnik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Zaghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Hendizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Q","family":"Gopen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2015,2,12]]},"reference":[{"key":"S002221511500016X_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8240.1997.tb00913.x"},{"key":"S002221511500016X_ref4","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1988.59.2.112"},{"key":"S002221511500016X_ref24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3928\/0147-7447-20050501-20","article-title":"Minocycline-induced black bone disease","volume":"28","author":"Hepburn","year":"2005","journal-title":"Orthopedics"},{"key":"S002221511500016X_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S1068-607X(96)00033-9"},{"key":"S002221511500016X_ref21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6044.1109"},{"key":"S002221511500016X_ref14","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-122-2-199501150-00001"},{"key":"S002221511500016X_ref1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199818060-00004"},{"key":"S002221511500016X_ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.stomax.2009.03.010"},{"key":"S002221511500016X_ref26","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21656"},{"key":"S002221511500016X_ref9","doi-asserted-by":"publisher","DOI":"10.3928\/01477447-20120426-30"},{"key":"S002221511500016X_ref2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05497.x"},{"key":"S002221511500016X_ref3","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.5.669"},{"key":"S002221511500016X_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2003.11.006"},{"key":"S002221511500016X_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-8807(99)00023-X"},{"key":"S002221511500016X_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80128-3"},{"key":"S002221511500016X_ref11","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-200401000-00023"},{"key":"S002221511500016X_ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1982.01650240033017"},{"key":"S002221511500016X_ref13","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200203070-00005"},{"key":"S002221511500016X_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02108.x"},{"key":"S002221511500016X_ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2003.01756_2.x"},{"key":"S002221511500016X_ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2011.01.011"},{"key":"S002221511500016X_ref25","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20385"},{"key":"S002221511500016X_ref16","doi-asserted-by":"publisher","DOI":"10.4055\/cios.2012.4.3.181"},{"key":"S002221511500016X_ref5","first-page":"414","article-title":"Discoloration of teeth from tetracyclines \u2013 even today?","volume":"121","author":"Antonini","year":"2011","journal-title":"Research and Science"},{"key":"S002221511500016X_ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8240.1998.tb00355.x"},{"key":"S002221511500016X_ref23","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(04)80008-8"}],"container-title":["The Journal of Laryngology &amp; 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