{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:29Z","timestamp":1792020809470,"version":"4.4.0"},"reference-count":19,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T00:00:00Z","timestamp":1423180800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Laryngol. Otol."],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec id=\"S0022215115000171_sec1\"><jats:title>Objective:<\/jats:title><jats:p>This study aimed to investigate the long-term efficacy of intratympanic methylprednisolone perfusion treatment for intractable M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000171_sec2\"><jats:title>Methods:<\/jats:title><jats:p>A retrospective analysis of 17 intractable M\u00e9ni\u00e8re's disease patients treated with intratympanic methylprednisolone perfusion was performed. Treatment efficacy was evaluated according to the American Academy of Otolaryngology\u2013Head and Neck Surgery criteria. Short and long-term control or improvement rates were calculated after 6 and 24 months, respectively.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000171_sec3\"><jats:title>Results:<\/jats:title><jats:p>Sixteen patients were followed for more than two years. Short- and long-term vertigo control rates were 94 per cent and 81 per cent, respectively; short- and long-term functional activity improvements were 94 per cent and 88 per cent, respectively. The pure tone average was 53\u00a0\u00b1\u00a014\u00a0dB before treatment, and 50\u00a0\u00b1\u00a016\u00a0dB at 6 months and 52\u00a0\u00b1\u00a020\u00a0dB at 24 months after intratympanic methylprednisolone perfusion. Tinnitus was controlled or improved in five patients over the two-year follow-up period.<\/jats:p><\/jats:sec><jats:sec id=\"S0022215115000171_sec4\"><jats:title>Conclusion:<\/jats:title><jats:p>Intratympanic methylprednisolone perfusion can effectively control vertigo and improve functional activity in intractable M\u00e9ni\u00e8re's disease patients with good hearing preservation. It may therefore be a viable alternative treatment for intractable M\u00e9ni\u00e8re's disease.<\/jats:p><\/jats:sec>","DOI":"10.1017\/s0022215115000171","type":"journal-article","created":{"date-parts":[[2015,2,6]],"date-time":"2015-02-06T07:39:58Z","timestamp":1423208398000},"page":"232-237","source":"Crossref","is-referenced-by-count":15,"title":["Long-term effects of intratympanic methylprednisolone perfusion treatment on intractable M\u00e9ni\u00e8re's disease"],"prefix":"10.1017","volume":"129","author":[{"given":"W","family":"She","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2015,2,6]]},"reference":[{"key":"S0022215115000171_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.05.010"},{"key":"S0022215115000171_ref16","article-title":"Intratympanic steroids for M\u00e9ni\u00e8re's disease or syndrome","volume":"6","author":"Phillips","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"S0022215115000171_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e31815dbafc"},{"key":"S0022215115000171_ref18","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3182868312"},{"key":"S0022215115000171_ref1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812472882"},{"key":"S0022215115000171_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(93)90072-H"},{"key":"S0022215115000171_ref19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/mao.0b013e3180577963","article-title":"Current management of M\u00e9ni\u00e8re's disease in an only hearing ear","volume":"28","author":"Peterson","year":"2007","journal-title":"Otol Neurotol"},{"key":"S0022215115000171_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2012.11.008"},{"key":"S0022215115000171_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61161-7"},{"key":"S0022215115000171_ref5","article-title":"Intratympanic gentamicin for M\u00e9ni\u00e8re's disease or syndrome","volume":"16","author":"Pullens","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"S0022215115000171_ref6","doi-asserted-by":"publisher","DOI":"10.1177\/0194599811429432"},{"key":"S0022215115000171_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(02)00021-X"},{"key":"S0022215115000171_ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199907001-00001"},{"key":"S0022215115000171_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(95)70102-8"},{"key":"S0022215115000171_ref12","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109131486"},{"key":"S0022215115000171_ref14","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.5.2502"},{"key":"S0022215115000171_ref17","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21335"},{"key":"S0022215115000171_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2009.10.046"},{"key":"S0022215115000171_ref8","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0b013e3181c34e53"}],"container-title":["The Journal of Laryngology &amp; Otology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0022215115000171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T19:14:15Z","timestamp":1651173255000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0022215115000171\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,6]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["S0022215115000171"],"URL":"https:\/\/doi.org\/10.1017\/s0022215115000171","relation":{},"ISSN":["0022-2151","1748-5460"],"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,6]]}}}